Table 1: Characteristics of five patients with Whipple’s disease diagnosed in the period 1994–2013.

PatientGenderAge at the diagnosis
(time to diagnosis)
Clinical symptomsTreatmentOutcome*

# 1Male49 years
(3 years)
Weight loss (20 kg);
microcytic anaemia; metabolic bone disease
i.v. penicillin G + i.v. gentamicin for two weeks;
p.o. doxycycline
(100 mg per day) +
p.o. salazopyrine
(3 g per day)
for 1 year
Full remission

# 2Male53 years
(12 months)
Weight loss (11 kg);
diarrhoea;
microcytic anaemia;
headache;
dyspnoea;
orthostatic hypotension;
skin rash
i.v. amoxicillin-clavulanic acid + i.v. gentamicin for two weeks;
p.o. doxycycline
(100 mg per day) +
p.o. salazopyrine
(3 g per day)
for 1 year
Full remission

# 3Male44 years
(6 months)
Weight loss (18 kg); diarrhoea;
severe malabsorption;
severe kwashiorkor-type
malnutrition;
metabolic bone disease
i.v. amoxicillin-clavulanic acid + i.v. gentamicin for two weeks;
p.o. doxycycline
(100 mg per day) +
p.o. salazopyrine
(3 g per day)
for 1 year
Full remission

# 4Female58 years
(6 months)
Arthralgias;
weight loss (10.5 kg);
diarrhoea;
malnutrition;
microcytic anaemia
i.v. amoxicillin-clavulanic acid + i.v. gentamicin for two weeks;
p.o. doxycycline
(100 mg per day) +
p.o. salazopyrine
(3 g per day)
for 1 year
Full remission

# 5Female24 years**  
(12 months)
Arthralgias;
peripheral and abdominal lymph nodes;
muscle weakness;
fatigue
i.v. penicillin G + i.v. gentamicin for two weeks;
p.o. doxycycline
(100 mg per day) +
p.o. salazopyrine
(3 g per day)
for 1 year
Full remission

Notes. Clinical, endoscopic, and laboratory outcome after one year of treatment.
**Patient no. 5: a 59-year-old female was referred to our University Department because of the second relapse of Whipple’s disease after 18 years (the first onset at 24 and the first relapse at 41 years).