- About this Journal
- Abstracting and Indexing
- Aims and Scope
- Article Processing Charges
- Articles in Press
- Author Guidelines
- Bibliographic Information
- Citations to this Journal
- Contact Information
- Editorial Board
- Editorial Workflow
- Free eTOC Alerts
- Publication Ethics
- Reviewers Acknowledgment
- Submit a Manuscript
- Subscription Information
- Table of Contents
Gastroenterology Research and Practice
Volume 2013 (2013), Article ID 504816, 8 pages
Changes in Ghrelin-Related Factors in Gastroesophageal Reflux Disease in Rats
1Tsumura & Co., Tsumura Research Laboratories, 3586 Yoshiwara, Ami-machi, Inashiki-gun, Ibaraki 300-1192, Japan
2Department of Gastroenterology and Hematology, Hokkaido University Graduate School of Medicine, N15 W7 Kita-ku, Sapporo, Hokkaido 060-8638, Japan
3Department of Pathophysiology and Therapeutics, Division of Pharmasciences, Faculty of Pharmaceutical Sciences, Hokkaido University, N12 W6 Kita-ku, Sapporo, Hokkaido 060-0812, Japan
Received 21 December 2012; Revised 5 March 2013; Accepted 9 March 2013
Academic Editor: Ping-I Hsu
Copyright © 2013 Miwa Nahata et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
- R. Fass, “Therapeutic options for refractory gastroesophageal reflux disease,” Journal of Gastroenterology and Hepatology, vol. 27, supplement 3, pp. 3–7, 2012.
- L. F. Johnson and T. R. Demeester, “Twenty four hour pH monitoring of the distal esophagus. A quantitative measure of gastroesophageal reflux,” American Journal of Gastroenterology, vol. 62, no. 4, pp. 325–332, 1974.
- A. Asakawa, A. Inui, T. Kaga et al., “Ghrelin is an appetite-stimulatory signal from stomach with structural resemblance to motilin,” Gastroenterology, vol. 120, no. 2, pp. 337–345, 2001.
- G. J. Dockray, “Cholecystokinin,” Current Opinion in Endocrinology, Diabetes and Obesity, vol. 19, no. 1, pp. 8–12, 2012.
- J. G. Mercer, N. Hoggard, L. M. Williams, C. B. Lawrence, L. T. Hannah, and P. Trayhurn, “Localization of leptin receptor mRNA and the long form splice variant (Ob-Rb) in mouse hypothalamus and adjacent brain regions by in situ hybridization,” FEBS Letters, vol. 387, no. 2-3, pp. 113–116, 1996.
- Y. Date, K. Toshinai, S. Koda et al., “Peripheral interaction of ghrelin with cholecystokinin on feeding regulation,” Endocrinology, vol. 146, no. 8, pp. 3518–3525, 2005.
- M. Kojima, H. Hosoda, Y. Date, M. Nakazato, H. Matsuo, and K. Kangawa, “Ghrelin is a growth-hormone-releasing acylated peptide from stomach,” Nature, vol. 402, no. 6762, pp. 656–660, 1999.
- N. Omura, H. Kashiwagi, G. Chen, Y. Suzuki, F. Yano, and T. Aoki, “Establishment of surgically induced chronic acid reflux esophagitis in rats,” Scandinavian Journal of Gastroenterology, vol. 34, no. 10, pp. 948–953, 1999.
- H. Miwa, J. Koseki, T. Oshima et al., “Rikkunshito, a traditional Japanese medicine, may relieve abdominal symptoms in rats with experimental esophagitis by improving the barrier function of epithelial cells in esophageal mucosa,” Journal of Gastroenterology, vol. 45, no. 5, pp. 478–487, 2010.
- H. Takeda, C. Sadakane, T. Hattori et al., “Rikkunshito, an herbal medicine, suppresses cisplatin-induced anorexia in rats Via 5-HT2 receptor antagonism,” Gastroenterology, vol. 134, no. 7, pp. 2004–2013, 2008.
- M. Nakazato, N. Murakami, Y. Date et al., “A role for ghrelin in the central regulation of feeding,” Nature, vol. 409, no. 6817, pp. 194–198, 2001.
- M. Nahata, S. Muto, N. Oridate, et al., “Impaired ghrelin signaling is associated with gastrointestinal dysmotility in rats with gastroesophageal reflux disease,” American Journal of Physiology Gastrointestinal and Liver Physiology, vol. 303, no. 1, pp. G42–G53, 2012.
- Y. Date, N. Murakami, K. Toshinai et al., “The role of the gastric afferent vagal nerve in Ghrelin-induced feeding and growth hormone secretion in rats,” Gastroenterology, vol. 123, no. 4, pp. 1120–1128, 2002.
- H. Kirchner, J. A. Gutierrez, P. J. Solenberg, et al., “GOAT links dietary lipids with the endocrine control of energy balance,” Nature Medicine, vol. 15, no. 7, pp. 741–745, 2009.
- J. P. Camina, “Cell biology of the ghrelin receptor,” Journal of Neuroendocrinology, vol. 18, no. 1, pp. 65–76, 2006.
- M. W. Schwartz, R. J. Seeley, L. A. Campfield, P. Burn, and D. G. Baskin, “Identification of targets of leptin action in rat hypothalamus,” Journal of Clinical Investigation, vol. 98, no. 5, pp. 1101–1106, 1996.
- T. M. Mizuno, S. P. Kleopoulos, H. T. Bergen, J. L. Roberts, C. A. Priest, and C. V. Mobbs, “Hypothalamic pro-opiomelanocortin mRNA is reduced by fasting in ob/ob and db/db mice, but is stimulated by leptin,” Diabetes, vol. 47, no. 2, pp. 294–297, 1998.
- T. Sakurai, A. Amemiya, M. Ishii et al., “Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior,” Cell, vol. 92, no. 4, pp. 573–585, 1998.
- C. F. Elias, C. B. Saper, E. Maratos-Flier, et al., “Chemically defined projections linking the mediobasal hypothalamus and the lateral hypothalamic area,” Journal of Comparative Neurology, vol. 402, no. 4, pp. 442–459, 1998.
- D. Qu, D. S. Ludwig, S. Gammeltoft et al., “A role for melanin-concentrating hormone in the central regulation of feeding behaviour,” Nature, vol. 380, no. 6571, pp. 243–247, 1996.
- K. Toshinai, Y. Date, N. Murakami et al., “Ghrelin-induced food intake is mediated via the orexin pathway,” Endocrinology, vol. 144, no. 4, pp. 1506–1512, 2003.
- M. Shimada, N. A. Tritos, B. B. Lowell, J. S. Flier, and E. Maratos-Flier, “Mice lacking melanin-concentrating hormone are hypophagic and lean,” Nature, vol. 396, no. 6712, pp. 670–679, 1998.
- S. Mashiko, A. Ishihara, A. Gomori et al., “Antiobesity effect of a melanin-concentrating hormone 1 receptor antagonist in diet-induced obese mice,” Endocrinology, vol. 146, no. 7, pp. 3080–3086, 2005.
- D. J. Marsh, D. T. Weingarth, D. E. Novi, et al., “Melanin-concentrating hormone 1 receptor-deficient mice are lean, hyperactive, and hyperphagic and have altered metabolism,” Proceedings of the National Academy of Sciences of the United States of America, vol. 99, no. 5, pp. 3240–3245, 2002.
- G. C. Harris, M. Wimmer, and G. Aston-Jones, “A role for lateral hypothalamic orexin neurons in reward seeking,” Nature, vol. 437, no. 7058, pp. 556–559, 2005.
- A. Sherwood, M. Wosiski-Kuhn, T. Nguyen, et al., “The role of melanin-concentrating hormone in conditioned reward learning,” European Journal of Neuroscience, vol. 36, no. 8, pp. 3126–3133, 2012.
- H. Miwa, T. Oshima, J. Sakurai et al., “Experimental oesophagitis in the rat is associated with decreased voluntary movement,” Neurogastroenterology and Motility, vol. 21, no. 3, pp. 296–303, 2009.