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Gastroenterology Research and Practice
Volume 2013 (2013), Article ID 518483, 9 pages
http://dx.doi.org/10.1155/2013/518483
Review Article

Update on the Diagnosis and Management of Refractory Coeliac Disease

Department of Gastroenterology, VU University Medical Center, De Boelelaan 1118, 1081 HZ Amsterdam, The Netherlands

Received 6 March 2013; Accepted 25 March 2013

Academic Editor: Marcela Kopacova

Copyright © 2013 Petula Nijeboer et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. G. J. Tack, W. H. M. Verbeek, M. W. J. Schreurs, and C. J. J. Mulder, “The spectrum of celiac disease: epidemiology, clinical aspects and treatment,” Nature Reviews Gastroenterology and Hepatology, vol. 7, no. 4, pp. 204–213, 2010. View at Publisher · View at Google Scholar · View at Scopus
  2. A. Al-Toma, W. H. M. Verbeek, and C. J. J. Mulder, “Update on the management of refractory coeliac disease,” Journal of Gastrointestinal and Liver Diseases, vol. 16, no. 1, pp. 57–63, 2007. View at Scopus
  3. P. J. Wahab, J. W. R. Meijer, and C. J. J. Mulder, “Histologic follow-up of people with celiac disease on a gluten-free diet: slow and incomplete recovery,” American Journal of Clinical Pathology, vol. 118, no. 3, pp. 459–463, 2002. View at Publisher · View at Google Scholar · View at Scopus
  4. A. Lanzini, F. Lanzarotto, V. Villanacci et al., “Complete recovery of intestinal mucosa occurs very rarely in adult coeliac patients despite adherence to gluten-free diet,” Alimentary Pharmacology & Therapeutics, vol. 29, no. 12, pp. 1299–1308, 2009. View at Scopus
  5. K. Kaukinen, M. Peräaho, K. Lindfors et al., “Persistent small bowel mucosal villous atrophy without symptoms in coeliac disease,” Alimentary Pharmacology & Therapeutics, vol. 25, no. 10, pp. 1237–1245, 2007. View at Publisher · View at Google Scholar · View at Scopus
  6. C. J. J. Mudler, “When is a coeliac a coeliac? Report of a working group of the United European Gastroenterology Week in Amsterdam, 2001,” European Journal of Gastroenterology and Hepatology, vol. 13, no. 9, pp. 1123–1128, 2001. View at Publisher · View at Google Scholar · View at Scopus
  7. A. Al-Toma, W. H. M. Verbeek, M. Hadithi, B. M. E. von Blomberg, and C. J. J. Mulder, “Survival in refractory coeliac disease and enteropathy-associated T-cell lymphoma: retrospective evaluation of single-centre experience,” Gut, vol. 56, no. 10, pp. 1373–1378, 2007. View at Publisher · View at Google Scholar · View at Scopus
  8. A. Rubio-Tapia, D. G. Kelly, B. D. Lahr, A. Dogan, T. T. Wu, and J. A. Murray, “Clinical staging and survival in refractory celiac disease: a single center experience,” Gastroenterology, vol. 136, no. 1, pp. 99–107, 2009. View at Publisher · View at Google Scholar · View at Scopus
  9. G. Malamut, P. Afchain, V. Verkarre et al., “Presentation and long-term follow-up of refractory celiac disease: comparison of type I with type II,” Gastroenterology, vol. 136, no. 1, pp. 81–90, 2009. View at Publisher · View at Google Scholar · View at Scopus
  10. J. West, “Celiac disease and its complications: a time traveller's perspective,” Gastroenterology, vol. 136, no. 1, pp. 32–34, 2009. View at Publisher · View at Google Scholar · View at Scopus
  11. B. Roshan, D. A. Leffler, S. Jamma et al., “The incidence and clinical spectrum of refractory celiac disease in a north american referral center,” American Journal of Gastroenterology, vol. 106, no. 5, pp. 923–928, 2011. View at Publisher · View at Google Scholar · View at Scopus
  12. A. Rubio-Tapia and J. A. Murray, “Classification and management of refractory coeliac disease,” Gut, vol. 59, no. 4, pp. 547–557, 2010. View at Publisher · View at Google Scholar · View at Scopus
  13. A. Al-Toma, W. H. M. Verbeek, and C. J. J. Mulder, “The management of complicated celiac disease,” Digestive Diseases, vol. 25, no. 3, pp. 230–236, 2007. View at Publisher · View at Google Scholar · View at Scopus
  14. S. Daum, C. Cellier, and C. J. J. Mulder, “Refractory coeliac disease,” Best Practice and Research, vol. 19, no. 3, pp. 413–424, 2005. View at Publisher · View at Google Scholar · View at Scopus
  15. M. Hadithi, B. M. E. von Blomberg, J. B. A. Crusius et al., “Accuracy of serologic tests and HLA-DQ typing for diagnosing celiac disease,” Annals of Internal Medicine, vol. 147, no. 5, pp. 294–302, 2007. View at Scopus
  16. S. J. van Weyenberg, F. Smits, M. A. Jacobs, S. T. van Turenhout, and C. J. Mulder, “Video capsule endoscopy in patients with nonresponsive celiac disease,” Journal of Clinical Gastroenterology, 2012. View at Publisher · View at Google Scholar
  17. M. Hadithi, A. Al-Toma, J. Oudejans, A. A. van Bodegraven, C. J. Mulder, and M. Jacobs, “The value of double-balloon enteroscopy in patients with refractory celiac disease,” American Journal of Gastroenterology, vol. 102, no. 5, pp. 987–996, 2007. View at Publisher · View at Google Scholar · View at Scopus
  18. C. J. J. Mulder, P. J. Wahab, B. Moshaver, and J. W. R. Meijer, “Refractory coeliac disease: a window between coeliac disease and enteropathy associated T cell lymphoma,” Scandinavian Journal of Gastroenterology, Supplement, vol. 35, no. 232, pp. 32–37, 2000. View at Scopus
  19. G. Malamut, B. Meresse, C. Cellier, and N. Cerf-Bensussan, “Refractory celiac disease: from bench to bedside,” Seminars in Immunopathology, vol. 34, pp. 601–613, 2012.
  20. C. Cellier, N. Patey, L. Mauvieux et al., “Abnormal intestinal intraepithelial lymphocytes in refractory sprue,” Gastroenterology, vol. 114, no. 3, pp. 471–481, 1998. View at Publisher · View at Google Scholar · View at Scopus
  21. A. Al-Toma, W. H. M. Verbeek, M. Hadithi, B. M. E. von Blomberg, and C. J. J. Mulder, “Survival in refractory coeliac disease and enteropathy-associated T-cell lymphoma: retrospective evaluation of single-centre experience,” Gut, vol. 56, no. 10, pp. 1373–1378, 2007. View at Publisher · View at Google Scholar · View at Scopus
  22. R. L. J. van Wanrooij, M. W. J. Schreurs, G. Bouma et al., “Accurate classification of RCD requires flow cytometry,” Gut, vol. 59, no. 12, article 1732, 2010. View at Publisher · View at Google Scholar · View at Scopus
  23. G. J. Tack, R. L. van Wanrooij, A. W. Langerak et al., “Origin and immunophenotype of aberrant IEL in RCDII patients,” Molecular Immunology, vol. 50, pp. 262–270, 2012.
  24. M. Mallant, M. Hadithi, A. B. Al-Toma et al., “Abdominal computed tomography in refractory coeliac disease and enteropathy associated T-cell lymphoma,” World Journal of Gastroenterology, vol. 13, no. 11, pp. 1696–1700, 2007. View at Scopus
  25. S. J. B. van Weyenberg, S. T. V. Turenhout, G. Bouma et al., “Double-balloon endoscopy as the primary method for small-bowel video capsule endoscope retrieval,” Gastrointestinal Endoscopy, vol. 71, no. 3, pp. 535–541, 2010. View at Publisher · View at Google Scholar · View at Scopus
  26. S. J. van Weyenberg, K. Bouman, M. A. Jacobs et al., “Comparison of MR enteroclysis with video capsule endoscopy in the investigation of small-intestinal disease,” Abdom Imaging, vol. 38, no. 1, pp. 42–51, 2013.
  27. S. Daum, U. Wahnschaffe, R. Glasenapp et al., “Capsule endoscopy in refractory celiac disease,” Endoscopy, vol. 39, pp. 455–458, 2007.
  28. G. Trynka, K. A. Hunt, N. A. Bockett, et al., “Dense genotyping identifies and localizes multiple common and rare variant association signals in celiac disease,” Nature Genetics, vol. 43, pp. 1193–1201, 2011.
  29. V. M. Wolters and C. Wijmenga, “Genetic background of celiac disease and its clinical implications,” American Journal of Gastroenterology, vol. 103, no. 1, pp. 190–195, 2008. View at Publisher · View at Google Scholar · View at Scopus
  30. A. Al-Toma, M. S. Goerres, J. W. R. Meijer, A. S. Peña, J. B. A. Crusius, and C. J. J. Mulder, “Human leukocyte antigen-DQ2 homozygosity and the development of refractory celiac disease and enteropathy-associated T-cell lymphoma,” Clinical Gastroenterology and Hepatology, vol. 4, no. 3, pp. 315–319, 2006. View at Publisher · View at Google Scholar · View at Scopus
  31. A. di Sabatino, F. Biagi, P. G. Gobbi, and G. R. Corazza, “How I treat enteropathy-associated T-cell lymphoma,” Blood, vol. 119, pp. 2458–2468, 2012.
  32. O. Olen, J. Askling, J. F. Ludvigsson, H. Hildebrand, A. Ekbom, and K. E. Smedby, “Coeliac disease characteristics, compliance to a gluten free diet and risk of lymphoma by subtype,” Digestive and Liver Disease, vol. 43, pp. 862–868, 2011.
  33. van Wanrooij, et al., 2013, manuscript in preparation.
  34. W. H. M. Verbeek, M. S. Goerres, B. M. E. von Blomberg et al., “Flow cytometric determination of aberrant intra-epithelial lymphocytes predicts T-cell lymphoma development more accurately than T-cell clonality analysis in Refractory Celiac disease,” Clinical Immunology, vol. 126, no. 1, pp. 48–56, 2008. View at Publisher · View at Google Scholar · View at Scopus
  35. G. J. Tack, R. L. van Wanrooij, B. M. von Blomberg et al., “Serum parameters in the spectrum of coeliac disease: beyond standard antibody testing—a cohort study,” BMC Gastroenterol, vol. 12, article 159, 2012.
  36. F. Schmitz, J. M. Tjon, Y. Lai et al., “Identification of a potential physiological precursor of aberrant cells in refractory coeliac disease type II,” Gut, vol. 62, no. 4, pp. 509–519.
  37. J. J. Mention, M. B. Ahmed, B. Bègue et al., “Interleukin 15: a key to disrupted intraepithelial lymphocyte homeostasis and lymphomagenesis in celiac disease,” Gastroenterology, vol. 125, no. 3, pp. 730–745, 2003. View at Publisher · View at Google Scholar · View at Scopus
  38. S. L. Colpitts, T. A. Stoklasek, C. R. Plumlee, J. J. Obar, C. Guo, and L. Lefrancois, “Cutting edge: the role of IFN-alpha receptor and MyD88 signaling in induction of IL-15 expression in vivo,” The Journal of Immunology, vol. 188, pp. 2483–2487, 2012.
  39. P. Brar, S. Lee, S. Lewis, I. Egbuna, G. Bhagat, and P. H. R. Green, “Budesonide in the treatment of refractory celiac disease,” American Journal of Gastroenterology, vol. 102, no. 10, pp. 2265–2269, 2007. View at Publisher · View at Google Scholar · View at Scopus
  40. S. Jamma, D. A. Leffler, M. Dennis et al., “Small intestinal release mesalamine for the treatment of refractory celiac disease type I,” Journal of Clinical Gastroenterology, vol. 45, no. 1, pp. 30–33, 2011. View at Publisher · View at Google Scholar · View at Scopus
  41. M. S. Goerres, J. W. R. Meijer, P. J. Wahab et al., “Azathioprine and prednisone combination therapy in refractory coeliac disease,” Alimentary Pharmacology & Therapeutics, vol. 18, no. 5, pp. 487–494, 2003. View at Publisher · View at Google Scholar · View at Scopus
  42. H. R. Gillett, I. D. R. Arnott, M. McIntyre et al., “Successful infliximab treatment for steroid-refractory celiac disease: a case report,” Gastroenterology, vol. 122, no. 3, pp. 800–805, 2002. View at Scopus
  43. G. Costantino, A. della Torre, M. A. lo Presti, R. Caruso, E. Mazzon, and W. Fries, “Treatment of life-threatening type I refractory coeliac disease with long-term infliximab,” Digestive and Liver Disease, vol. 40, no. 1, pp. 74–77, 2008. View at Publisher · View at Google Scholar · View at Scopus
  44. G. J. Tack, D. P. van Asseldonk, R. L. van Wanrooij, A. A. van Bodegraven, and C. J. Mulder, “Tioguanine in the treatment of refractory coeliac disease—a single centre experience,” Alimentary Pharmacology & Therapeutics, vol. 36, pp. 274–281, 2012.
  45. G. Malamut, P. Afchain, V. Verkarre et al., “Presentation and long-term follow-up of refractory celiac disease: comparison of type I with type II,” Gastroenterology, vol. 136, no. 1, pp. 81–90, 2009. View at Publisher · View at Google Scholar · View at Scopus
  46. T. Robak, A. Wierzbowska, and E. Robak, “Recent clinical trials of cladribine in hematological malignancies and autoimmune disorders,” Reviews on Recent Clinical Trials, vol. 1, no. 1, pp. 15–34, 2006. View at Publisher · View at Google Scholar · View at Scopus
  47. G. J. Tack, W. H. M. Verbeek, A. Al-Toma et al., “Evaluation of cladribine treatment in refractory celiac disease type II,” World Journal of Gastroenterology, vol. 17, no. 4, pp. 506–513, 2011. View at Publisher · View at Google Scholar · View at Scopus
  48. A. Al-Toma, M. S. Goerres, J. W. R. Meijer et al., “Cladribine therapy in refractory celiac disease with aberrant T cells,” Clinical Gastroenterology and Hepatology, vol. 4, no. 11, pp. 1322–1327, 2006. View at Publisher · View at Google Scholar · View at Scopus
  49. A. Tyndall, A. Fassas, J. Passweg et al., “Autologous haematopoietic stem cell transplants for autoimmune disease—feasibility and transplant-related mortality,” Bone Marrow Transplantation, vol. 24, no. 7, pp. 729–734, 1999. View at Scopus
  50. A. Gratwohl, J. Passweg, C. Bocelli-Tyndall et al., “Autologous hematopoietic stem cell transplantation for autoimmune diseases,” Bone Marrow Transplantation, vol. 35, no. 9, pp. 869–879, 2005. View at Publisher · View at Google Scholar · View at Scopus
  51. J. Passweg and A. Tyndall, “Autologous stem cell transplantation in autoimmune diseases,” Seminars in Hematology, vol. 44, no. 4, pp. 278–285, 2007. View at Publisher · View at Google Scholar · View at Scopus
  52. A. Al-Toma, O. J. Visser, H. M. van Roessel et al., “Autologous hematopoietic stem cell transplantation in refractory celiac disease with aberrant T cells,” Blood, vol. 109, no. 5, pp. 2243–2249, 2007. View at Publisher · View at Google Scholar · View at Scopus
  53. G. J. Tack, M. J. Wondergem, A. Al-Toma et al., “Auto-SCT in refractory celiac disease type II patients unresponsive to cladribine therapy,” Bone Marrow Transplantation, vol. 46, no. 6, pp. 840–846, 2011. View at Publisher · View at Google Scholar · View at Scopus
  54. P. J. Wahab, J. B. Crusius, J. W. Meijer, J. J. Uil, and C. J. Mulder, “Cyclosporin in the treatment of adults with refractory coeliac disease—an open pilot study,” Alimentary Pharmacology & Therapeutics, vol. 14, no. 6, pp. 767–774, 2000.
  55. J. Gale, P. D. Simmonds, G. M. Mead, J. W. Sweetenham, and D. H. Wright, “Enteropathy-type intestinal T-cell lymphoma: clinical features and treatment of 31 patients in a single center,” Journal of Clinical Oncology, vol. 18, no. 4, pp. 795–803, 2000. View at Scopus
  56. J. M. W. van de Water, S. A. G. M. Cillessen, O. J. Visser, W. H. M. Verbeek, C. J. L. M. Meijer, and C. J. J. Mulder, “Enteropathy associated T-cell lymphoma and its precursor lesions,” Best Practice and Research, vol. 24, no. 1, pp. 43–56, 2010. View at Publisher · View at Google Scholar · View at Scopus