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Gastroenterology Research and Practice
Volume 2013 (2013), Article ID 570597, 8 pages
http://dx.doi.org/10.1155/2013/570597
Research Article

Risk of Atherosclerosis and Helicobacter pylori Infection according to CD14 Promotor Polymorphism in Healthy Korean Population

1Department of Family Medicine, St. Vincent's Hospital, College of Medicine, The Catholic University of Korea, 93-6 Jungbu-daero, Paldal-gu, Suwon 442-723, Republic of Korea
2Department of Internal Medicine, St. Vincent's Hospital, College of Medicine, The Catholic University of Korea, 93-6 Jungbu-daero, Paldal-gu, Suwon 442-723, Republic of Korea

Received 12 June 2013; Accepted 28 August 2013

Academic Editor: Tun-Chieh Chen

Copyright © 2013 Sung-Goo Kang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Background and Aim. We aim to elucidate the association of risk factors for atherosclerosis and H. pylori infection according to the promotor polymorphism of the CD14 gene in healthy Korean population. Methods. The patients who visited our hospital for routine health examinations and 266 healthy adults (170 males and 96 females) were enrolled in this study. The promotor polymorphism at −159C/T of the CD14 gene was determined by PCR-restriction fragment length polymorphism analysis. According to genetic polymorphism and H. pylori infection, we analyzed the risk of atherosclerosis. Results. The genotype frequencies were CC 7.9%, CT 45.1%, and TT 47.0%, respectively. There were no differences between specific genotypes of CD14 gene and H. pylori infection rate. As for HDL cholesterol level, there were significant differences among the three genotypes ( ). In subjects with H. pylori infection, no significant differences were observed between specific genotypes of CD14 gene and the risk factors of atherosclerosis. Conclusion. The promotor polymorphism at −159C/T of the CD14 gene was associated with the risk factor of atherosclerosis in healthy Korean population. However, it was not associated with the rate of H. pylori infection and H. pylori induced atherosclerotic risk.