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Gastroenterology Research and Practice
Volume 2013 (2013), Article ID 574260, 7 pages
http://dx.doi.org/10.1155/2013/574260
Research Article

The Effect of Beta-Aminopropionitrile and Prednisolone on the Prevention of Fibrosis in Alkali Esophageal Burns: An Experimental Study

1Department of Emergency Medicine, Faculty of Medicine, Istanbul Bilim University, 34394 Istanbul, Turkey
2Department of General Surgery, Istanbul Faculty of Medicine, Istanbul University, 34093 Istanbul, Turkey
3Department of General Surgery, MoH Bagcilar Research and Training Hospital, 34200 Istanbul, Turkey
4Department of Emergency Medicine, MoH Bakirkoy Dr. Sadi Konuk Research and Training Hospital, 34147 Istanbul, Turkey
5Department of Histology and Embryology, Cerrahpasa Faculty of Medicine, Istanbul University, 34098 Istanbul, Turkey
6Department of Emergency Medicine, MoH Istanbul Research and Training Hospital, 34098 Istanbul, Turkey
7Department of Emergency Medicine, MoH Okmeydani Research and Training Hospital, 34384 Istanbul, Turkey
8Department of Emergency, MoH Avcilar State Hospital, 34320 Istanbul, Turkey
9Department of Emergency Medicine, MoH Kartal Lutfi Kırdar Research and Training Hospital, 34880 Istanbul, Turkey

Received 23 August 2013; Revised 1 November 2013; Accepted 6 November 2013

Academic Editor: Vikram Kate

Copyright © 2013 Kurtulus Aciksari et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Objective. The aim of this study was to investigate the efficacy of beta-aminopropionitrile (BAPN) and prednisolone on the prevention of esophageal damage and stricture formation after caustic esophageal burn. Method. Twenty-eight rats were divided into four equal groups. In groups 1, 2, and 3, caustic esophageal burns were generated by applying NaOH to the 1.5 cm segment of the abdominal esophagus. Group 4 was for the sham. Normal saline to group 1, BAPN to group 2, and prednisolone to group 3 were administered intraperitoneally as a single daily dose. Results. Treatment with BAPN decreased the stenosis index (SI) and histopathologic damage score (HDS) seen in caustic esophageal burn rats. The SI in group 4 was significantly lower compared with groups 1, 2, and 3. Group 2 had the minimum SI value in corrosive burn groups. The differences related to SI between groups 1, 2, and 3 were not statistically significant. The HDS was significantly lower in group 4 compared with groups 1, 2, and 3. The HDS in group 2 was significantly lower compared with groups 1 and 3. Conclusion. This study demonstrated that BAPN was able to decrease the development of stenosis and tissue damage better than prednisolone.