Review Article
Current Advances in the Diagnosis and Treatment of Nonerosive Reflux Disease
Table 2
Clinical and physiological characteristics between patients with NERD and erosive esophagitis.
| | Characteristics | NERD | Erosive esophagitis |
| | Gender | Female | No difference | | Age (yr) | 40–50 | 50–60 | | Smoking (%) | 15–23 | 10–23 | | Alcohol (%) | 8–59 | 6–64 | | Symptom duration (yr) | 1–5 | 1–5 | | Hiatal hernia (%) | 20–29 | 39–56 | | Helicobacter pylori (+) (%) | 34–41 | 20–26 | | Resting LES pressure | Normal | Normal to low | | Abnormal esophageal motility | Mild | Moderate to severe | | Esophageal acid clearance | Normal | Abnormal | | Distal esophageal pH (<4) (% of time) | Slightly increased | Moderately increased |
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NERD: nonerosive reflux disease; mild: ineffective esophageal motility alone; moderate to severe: ineffective esophageal motility and impaired bolus clearance.
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