Review Article
PP2A-Mediated Anticancer Therapy
Table 2
Cancer-associated mutations of PP2A A subunits.
| Subunit | Mutation name | Alternations | Consequence | Cancer type | References |
| PR65 | E64D E64G R418W
| Point mutation
| Deficiency in binding to B′α1 Deficiency in binding to B/C subunits | Breast Lung Skin
| [15, 17, 61] | 171-589 | Deletion | Breast |
| PR65 | G8R P65S G90D L101P L101P/V448A K343E V448A D504G V545A | Missense | Dysregulation of RalA GTPase, leading to impaired binding capacity to B/C subunits |
Lung Breast Colon | [12, 15, 43] | E344-E388 | In-frame deletion | [12, 15, 43] |
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