PP2A-Mediated Anticancer Therapy

Table 2

Cancer-associated mutations of PP2A A subunits.

Subunit	Mutation name	Alternations	Consequence	Cancer type	References
PR65𝛼	E64D; E64G; R418W	Point mutation	Deficiency in binding to B′α1; Deficiency in binding to B/C subunits	Breast; Lung; Skin	[15, 17, 61]
	Δ171-589	Deletion		Breast
PR65𝛽	G8R; P65S; G90D; L101P; L101P/V448A; K343E; V448A; D504G; V545A	Missense	Dysregulation of RalA GTPase, leading to impaired binding capacity to B/C subunits	Lung; Breast; Colon	[12, 15, 43]
	ΔE344-E388	In-frame deletion			[12, 15, 43]