- About this Journal ·
- Abstracting and Indexing ·
- Aims and Scope ·
- Annual Issues ·
- Article Processing Charges ·
- Articles in Press ·
- Author Guidelines ·
- Bibliographic Information ·
- Citations to this Journal ·
- Contact Information ·
- Editorial Board ·
- Editorial Workflow ·
- Free eTOC Alerts ·
- Publication Ethics ·
- Reviewers Acknowledgment ·
- Submit a Manuscript ·
- Subscription Information ·
- Table of Contents
Gastroenterology Research and Practice
Volume 2013 (2013), Article ID 683824, 7 pages
The Novel Crohn's Disease Marker Anti-GP2 Antibody Is Associated with Ileocolonic Location of Disease
1R/D, Medipan GmbH, 15827 Dahlewitz/Berlin, Germany
2Immunology Department, King Hussein Medical Center, Amman 11855, Jordan
3University of Jordan, Amman 11942, Jordan
4Department of Pediatrics, Polytechnic University of Marche, 60123 Ancona, Italy
5Department of Gastroenterology, “Ospedali Riuniti” University Hospital, 60020 Ancona, Italy
6Institute of Immunology, Technical University, 01307 Dresden, Germany
7Division of Transplantation Immunology and Mucosal Biology, Institute of Liver Studies, King’s College London School of Medicine at King’s College Hospital, Denmark Hill Campus, London SE5 9RJ, UK
8Faculty of Natural Sciences, Lausitz University of Applied Sciences, 01968 Senftenberg, Germany
9Central Analytical Laboratory, “Ospedali Riuniti” University Hospital, 60020 Ancona, Italy
Received 11 February 2013; Accepted 19 March 2013
Academic Editor: Devendra Amre
Copyright © 2013 Valentina Somma et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
- I. Logan and C. L. Bowlus, “The geoepidemiology of autoimmune intestinal diseases,” Autoimmunity Reviews, vol. 9, no. 5, pp. A372–A378, 2010.
- S. Shivananda, J. Lennard-Jones, R. Logan et al., “Incidence of inflammatory bowel disease across Europe: is there a difference between north and south? Results of the European collaborative study on inflammatory bowel disease (EC-IBD),” Gut, vol. 39, no. 5, pp. 690–697, 1996.
- E. V. Loftus Jr., P. Schoenfeld, and W. J. Sandborn, “The epidemiology and natural history of Crohn's disease in population-based patient cohorts from North America: a systematic review,” Alimentary Pharmacology and Therapeutics, vol. 16, no. 1, pp. 51–60, 2002.
- C. N. Bernstein, A. Wajda, L. W. Svenson et al., “The epidemiology of inflammatory bowel disease in Canada: a population-based study,” American Journal of Gastroenterology, vol. 101, no. 7, pp. 1559–1568, 2006.
- D. C. Baumgart and W. J. Sandborn, “Inflammatory bowel disease: clinical aspects and established and evolving therapies,” The Lancet, vol. 369, no. 9573, pp. 1641–1657, 2007.
- J. Cosnes, A. Bourrier, I. Nion-Larmurier, H. Sokol, L. Beaugerie, and P. Seksik, “Factors affecting outcomes in Crohn's disease over 15 years,” Gut, vol. 61, no. 8, pp. 1140–1145, 2012.
- J. E. Lennard-Jones, “Classification of inflammatory bowel disease,” Scandinavian Journal of Gastroenterology, Supplement, vol. 24, no. 170, pp. 2–6, 1989.
- Y. Ogura, D. K. Bonen, N. Inohara et al., “A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease,” Nature, vol. 411, no. 6837, pp. 603–606, 2001.
- A. P. Cuthbert, S. A. Fisher, M. M. Mirza et al., “The contribution of NOD2 gene mutations to the risk and site of disease in inflammatory bowel disease,” Gastroenterology, vol. 122, no. 4, pp. 867–874, 2002.
- H. Clevers, “Inflammatory bowel disease, stress, and the endoplasmic reticulum,” The New England Journal of Medicine, vol. 360, no. 7, pp. 726–727, 2009.
- D. C. Baumgart and S. R. Carding, “Inflammatory bowel disease: cause and immunobiology,” The Lancet, vol. 369, no. 9573, pp. 1627–1640, 2007.
- L. Jostins, S. Ripke, R. K. Weersma, et al., “Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease,” Nature, vol. 491, no. 7422, pp. 119–124, 2012.
- D. Roggenbuck, D. Reinhold, L. Werner, P. Schierack, D. P. Bogdanos, and K. Conrad, “Glycoprotein 2 antibodies in Crohn's disease,” Advances in Clinical Chemistry, vol. 60, pp. 187–208, 2013.
- A. Saxon, F. Shanahan, C. Landers, T. Ganz, and S. Targan, “A distinct subset of antineutrophil cytoplasmic antibodies is associated with inflammatory bowel disease,” Journal of Allergy and Clinical Immunology, vol. 86, no. 2, pp. 202–210, 1990.
- W. Stöcker, M. Otte, S. Ulrich, D. Normann, K. Stöcker, and G. Jantschek, “Autoantiköper gegen exokrines Pankreas und gegen intestinale Becherzellen in der Diagnostik des Morbus Crohn und der Colitis ulcerosa,” Deutsche Medizinische Wochenschrift, vol. 109, pp. 1963–1969, 1984.
- M. Barthet, P. Hastier, J. P. Bernard, G. Bordes, J. Frederick, and S. Allio, “Chronic pancreatitis and inflammatory bowel disease: true or coincidental association?” American Journal of Gastroenterology, vol. 94, no. 8, pp. 2141–2148, 1999.
- K. Conrad, H. Schmechta, A. Klafki et al., “Serological differentiation of inflammatory bowel diseases,” European Journal of Gastroenterology and Hepatology, vol. 14, no. 2, pp. 129–135, 2002.
- D. Roggenbuck, G. Hausdorf, L. Martinez-Gamboa et al., “Identification of GP2, the major zymogen granule membrane glycoprotein, as the autoantigen of pancreatic antibodies in Crohn's disease,” Gut, vol. 58, no. 12, pp. 1620–1628, 2009.
- T. C. Hoops, I. Ivanov, Z. Cui, V. Colomer-Gould, and M. J. Rindler, “Incorporation of the pancreatic membrane protein GP-2 into secretory granules in exocrine but not endocrine cells,” Journal of Biological Chemistry, vol. 268, no. 34, pp. 25694–25705, 1993.
- R. A. Ronzio, K. E. Kronquist, and D. S. Lewis, “Glycoprotein synthesis in the adult rat pancreas. IV. Subcellular distribution of membrane glycoproteins,” Biochimica et Biophysica Acta, vol. 508, no. 1, pp. 65–84, 1978.
- M. Gmez-Lzaro, C. Rinn, M. Aroso, F. Amado, and M. Schrader, “Proteomic analysis of zymogen granules,” Expert Review of Proteomics, vol. 7, no. 5, pp. 735–747, 2010.
- M. J. Rindler and T. C. Hoops, “The pancreatic membrane protein GP-2 localizes specifically to secretory granules and is shed into the pancreatic juice as a protein aggregate,” European Journal of Cell Biology, vol. 53, no. 1, pp. 154–163, 1990.
- K. Hase, K. Kawano, T. Nochi et al., “Uptake through glycoprotein 2 of FimH + bacteria by M cells initiates mucosal immune response,” Nature, vol. 462, no. 7270, pp. 226–230, 2009.
- H. T. T. Nguyen, A. B. Amine, D. Lafitte et al., “Proteomic characterization of lipid rafts markers from the rat intestinal brush border,” Biochemical and Biophysical Research Communications, vol. 342, no. 1, pp. 236–244, 2006.
- L. Werner, D. Paclik, C. Fritz, D. Reinhold, D. Roggenbuck, and A. Sturm, “Identification of pancreatic glycoprotein 2 as an endogenous immunomodulator of innate and adaptive immune responses,” The Journal of Immunology, vol. 189, no. 6, pp. 2774–2783, 2012.
- M. D. Säemann, T. Weichhart, M. Zeyda et al., “Tamm-Horsfall glycoprotein links innate immune cell activation with adaptive immunity via a Toll-like receptor-4-dependent mechanism,” Journal of Clinical Investigation, vol. 115, no. 2, pp. 468–475, 2005.
- S. Fukuoka, S. D. Freedman, H. Yu, V. P. Sukhatme, and G. A. Scheele, “GP-2/THP gene family encodes self-binding glycosylphosphatidylinositol-anchored proteins in apical secretory compartments of pancreas and kidney,” Proceedings of the National Academy of Sciences of the United States of America, vol. 89, no. 4, pp. 1189–1193, 1992.
- L. Komorowski, B. Teegen, C. Probst, et al., “Autoantibodies against exocrine pancreas in Crohn's disease are directed against two antigens: the glycoproteins CUZD1 and GP2,” Journal of Crohn's & Colitis, 2012.
- D. Roggenbuck, R. L. Humbel, D. Reinhold, D. P. Bogdanos, K. Conrad, and M. W. Laass, “Glycoprotein 2 antibodies in inflammatory bowel disease: no association with disease phenotype?” Journal of Pediatric Gastroenterology and Nutrition, vol. 56, no. 1, p. e5, 2012.
- D. Roggenbuck, D. Bogdanos, and K. Conrad, “Loss of tolerance to one or two major targets in Crohn's disease or just cross-reactivity?” Journal of Crohn's & Colitis, 2013.
- V. Colomer, K. Lal, T. C. Hoops, and M. J. Rindler, “Exocrine granule specific packaging signals are present in the polypeptide moiety of the pancreatic granule membrane protein GP2 and in amylase: implications for protein targeting to secretory granules,” The EMBO Journal, vol. 13, no. 16, pp. 3711–3719, 1994.
- S. Yu, S. A. Michie, and A. W. Lowe, “Absence of the major zymogen granule membrane protein, GP2, does not affect pancreatic morphology or secretion,” Journal of Biological Chemistry, vol. 279, no. 48, pp. 50274–50279, 2004.
- K. Kobayashi, K. Yanagihara, K. Ishiguro, and S. Fukuoka, “GP2/THP gene family of self-binding, GPI-anchored proteins forms a cluster at chromosome 7F1 region in mouse genome,” Biochemical and Biophysical Research Communications, vol. 322, no. 2, pp. 659–664, 2004.
- J. Pak, Y. Pu, Z. T. Zhang, D. L. Hasty, and X. R. Wu, “Tamm-Horsfall protein binds to type 1 fimbriated Escherichia coli and prevents E. coli from binding to uroplakin Ia and Ib receptors,” Journal of Biological Chemistry, vol. 276, no. 13, pp. 9924–9930, 2001.
- W. Dou, S. Thompson-Jaeger, S. J. F. Laulederkind et al., “Defective expression of Tamm-Horsfall protein/uromodulin in COX-2-deficient mice increases their susceptibility to urinary tract infections,” American Journal of Physiology, vol. 289, no. 1, pp. F49–F60, 2005.
- S. Yu and A. W. Lowe, “The pancreatic zymogen granule membrane protein, GP2, binds Escherichia coli type 1 Fimbriae,” BMC Gastroenterology, vol. 9, article 58, 2009.
- M. A. Hölzl, J. Hofer, J. J. Kovarik et al., “The zymogen granule protein 2 (GP2) binds to scavenger receptor expressed on endothelial cells I (SREC-I),” Cellular Immunology, vol. 267, no. 2, pp. 88–93, 2011.
- E. Gullberg and J. D. Söderholm, “Peyer's patches and M cells as potential sites of the inflammatory onset in Crohn's disease,” Annals of the New York Academy of Sciences, vol. 1072, pp. 218–232, 2006.
- P. L. Lakatos, M. Papp, and F. Rieder, “Serologic antiglycan antibodies in inflammatory bowel disease,” American Journal of Gastroenterology, vol. 106, no. 3, pp. 406–412, 2011.
- I. Dotan, “New serologic markers for inflammatory bowel disease diagnosis,” Digestive Diseases, vol. 28, no. 3, pp. 418–423, 2010.
- D. P. Bogdanos, E. I. Rigopoulou, D. S. Smyk, et al., “Diagnostic value, clinical utility and pathogenic significance of reactivity to the molecular targets of Crohn's disease specific-pancreatic autoantibodies,” Autoimmunity Reviews, vol. 11, no. 2, pp. 143–148, 2011.
- D. Roggenbuck, D. Reinhold, T. Wex et al., “Autoantibodies to GP2, the major zymogen granule membrane glycoprotein, are new markers in Crohn's disease,” Clinica Chimica Acta, vol. 412, no. 9-10, pp. 718–724, 2011.
- P. Pavlidis, M. G. Mytilinaiou, D. Roggenbuck, K. Conrad, A. Forbes, and D. P. Bogdanos, “Pancreatic GP2-specific autoantibodies are markers of Crohn's disease,” Gut, vol. 60, pp. A212–A213, 2011.
- K. Op de Beeck, S. Vermeire, P. Rutgeerts, and X. Bossuyt, “Antibodies to GP2, the major zymogen granule membrane glycoprotein, in inflammatory bowel diseases,” Gut, vol. 61, no. 1, pp. 162–164, 2010.
- M. Kovacs, P. L. Lakatos, M. Papp, et al., “Pancreatic autoantibodies and autoantibodies against goblet cells in pediatric patients with inflammatory bowel disease (IBD),” Journal of Pediatric Gastroenterology and Nutrition, vol. 55, no. 4, pp. 429–435, 2012.
- D. P. Bogdanos, D. Roggenbuck, D. Reinhold, et al., “Pancreatic-specific autoantibodies to glycoprotein 2 mirror disease location and behaviour in younger patients with Crohn's disease,” BMC Gastroenterology, vol. 12, p. 102, 2012.
- P. Pavlidis, O. Romanidou, D. Roggenbuck, et al., “Ileal inflammation may trigger the development of GP2-specific pancreatic autoantibodies in patients with Crohn's disease,” Clinical and Developmental Immunology, vol. 2012, Article ID 640835, 8 pages, 2012.
- H. J. Van Kruiningen, A. B. West, B. J. Freda, and K. A. Holmes, “Distribution of Peyer's patches in the distal ileum,” Inflammatory Bowel Diseases, vol. 8, no. 3, pp. 180–185, 2002.
- A. Darfeuille-Michaud, J. Boudeau, P. Bulois et al., “High prevalence of adherent-invasive Escherichia coli associated with ileal mucosa in Crohn's disease,” Gastroenterology, vol. 127, no. 2, pp. 412–421, 2004.
- L. A. G. Rodríguez, A. Ruigómez, and J. Panés, “Acute gastroenteritis is followed by an increased risk of inflammatory bowel disease,” Gastroenterology, vol. 130, no. 6, pp. 1588–1594, 2006.
- E. I. Rigopoulou, D. Roggenbuck, D. S. Smyk, et al., “Asialoglycoprotein receptor (ASGPR) as target autoantigen in liver autoimmunity: lost and found,” Autoimmunity Reviews, vol. 12, no. 2, pp. 260–269, 2012.
- D. Roggenbuck, M. G. Mytilinaiou, S. V. Lapin, D. Reinhold, and K. Conrad, “Asialoglycoprotein Receptor (ASGPR): APeculiar Target of Liver-Specific Autoimmunity,” Autoimmunity Highlights, vol. 3, no. 3, pp. 119–125, 2012.