Associations of miR-499 and miR-34b/c Polymorphisms with Susceptibility to Hepatocellular Carcinoma: An Evidence-Based Evaluation

Table 1

Characteristics of included studies.

Author	Year	Country	Ethnicity	SNP	Genotyping methods	𝑃 for HWE	Case genotype			Control genotype
							TT	TC	CC	TT	TC	CC
Akkiz	2011	Turkey	Caucasian	rs3746444	PCR-RFLP	0.036	45	87	90	47	93	82
Kim	2012	Korea	Asian	rs3746444	PCR-RFLP	0.278	109	47	3	120	74	7
Xiang	2012	China	Asian	rs3746444	PCR-RFLP	0.284	36	40	24	54	36	10
Zhou	2012	China	Asian	rs3746444	PCR-RFLP	0.620	141	41	4	371	100	12
Zou	2013	China	Asian	rs3746444	PCR-RFLP	0.005	136	44	5	123	48	14
Xu	2011	China	Asian	rs4938723	Real-time PCR	0.647	204	236	62	266	229	54
Son	2013	Korea	Asian	rs4938723	PCR-RFLP	0.371	69	75	13	110	74	17
Han	2013	China	Asian	rs4938723	PCR-RFLP	0.183	451	444	118	456	424	119

SNP: single nucleotide polymorphism; 𝑃 for HWE: 𝑃 value for Hardy-Weinberg equilibrium (HWE) calculated by Chi-square test. 𝑃<0.05 indicates deviation of genotype distribution from HWE.