About this Journal Submit a Manuscript Table of Contents
Gastroenterology Research and Practice
Volume 2013 (2013), Article ID 829040, 12 pages
http://dx.doi.org/10.1155/2013/829040
Review Article

Highlights in IBD Epidemiology and Its Natural History in the Paediatric Age

Unit of Paediatric Gastroenterology, Digestive Endoscopy, Hepatology, and Care of Children with Liver Transplantation, Department of Women’s and Children’s Health, University Hospital of Padova, Via Giustiniani 3, 35128 Padova, Italy

Received 30 August 2013; Revised 27 October 2013; Accepted 20 November 2013

Academic Editor: Andrew S. Day

Copyright © 2013 Marco Gasparetto and Graziella Guariso. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. J. Burisch and P. Munkholm, “Inflammatory bowel disease epidemiology,” Current Opinion in Gastroenterology, vol. 29, no. 4, pp. 357–362, 2013.
  2. E. I. Benchimol, A. Guttmann, A. M. Griffiths et al., “Increasing incidence of paediatric inflammatory bowel disease in Ontario, Canada: evidence from health administrative data,” Gut, vol. 58, no. 11, pp. 1490–1497, 2009. View at Publisher · View at Google Scholar · View at Scopus
  3. V. Chouraki, G. Savoye, L. Dauchet et al., “The changing pattern of Crohn's disease incidence in northern France: a continuing increase in the 10- to 19-year-old age bracket (1988–2007),” Alimentary Pharmacology and Therapeutics, vol. 33, no. 10, pp. 1133–1142, 2011. View at Publisher · View at Google Scholar · View at Scopus
  4. A. Jussila, L. J. Virta, V. Salomaa, J. Mäki, A. Jula, and M. A. Färkkilä, “High and increasing prevalence of inflammatory bowel disease in Finland with a clear North-South difference,” Journal of Crohn's and Colitis, vol. 7, no. 7, pp. e256–e262, 2013.
  5. J. Burisch, N. Pedersen, S. Cukovic-Cavka, et al., “East-West gradient in the incidence of inflammatory bowel disease in Europe: the ECCO-EpiCom inception cohort,” Gut. In press.
  6. P. Malmborg, L. Grahnquist, J. Lindholm, S. Montgomery, and H. Hildebrand, “Increasing incidence of paediatric inflammatory bowel disease in Northern stockholm county 2002–2007,” Journal of Pediatric Gastroenterology and Nutrition, vol. 57, no. 1, pp. 29–34.
  7. P. Turunen, K.-L. Kolho, A. Auvinen, S. Iltanen, H. Huhtala, and M. Ashorn, “Incidence of inflammatory bowel disease in Finnish children, 1987–2003,” Inflammatory Bowel Diseases, vol. 12, no. 8, pp. 677–683, 2006. View at Publisher · View at Google Scholar · View at Scopus
  8. A. Sawczenko and B. K. Sandhu, “Presenting features of inflammatory bowel disease in Great Britain and Ireland,” Archives of Disease in Childhood, vol. 88, no. 11, pp. 995–1000, 2003. View at Publisher · View at Google Scholar · View at Scopus
  9. E. L. Armitage, M. C. Aldhous, N. Anderson et al., “Incidence of juvenile-onset Crohn's disease in Scotland: association with northern latitude and affluence,” Gastroenterology, vol. 127, no. 4, pp. 1051–1057, 2004. View at Publisher · View at Google Scholar · View at Scopus
  10. O. Pozler, J. Maly, O. Bonova et al., “Incidence of Crohn disease in the Czech Republic in the years 1990 to 2001 and assessment of pediatric population with inflammatory bowel disease,” Journal of Pediatric Gastroenterology and Nutrition, vol. 42, no. 2, pp. 186–189, 2006. View at Publisher · View at Google Scholar · View at Scopus
  11. M. Castro, B. Papadatou, M. Baldassare et al., “Inflammatory bowel disease in children and adolescents in Italy: data from the pediatric national IBD register (1996–2003),” Inflammatory Bowel Diseases, vol. 14, no. 9, pp. 1246–1252, 2008. View at Publisher · View at Google Scholar · View at Scopus
  12. A. Rocchi, E. I. Benchimol, C. N. Bernstein et al., “Inflammatory bowel disease: a Canadian burden of illness review,” Canadian Journal of Gastroenterology, vol. 26, no. 11, pp. 811–817, 2012.
  13. Z. Zeng, Z. Zhu, Y. Yang et al., “Incidence and clinical characteristics of inflammatory bowel disease in a developed region of Guangdong province, China: a prospective population-based study,” Journal of Gastroenterology and Hepatology, vol. 28, no. 7, pp. 1148–1153, 2013.
  14. S. Kugathasan, R. H. Judd, R. G. Hoffmann et al., “Epidemiologic and clinical characteristics of children with newly diagnosed inflammatory bowel disease in Wisconsin: a statewide population-based study,” Journal of Pediatrics, vol. 143, no. 4, pp. 525–531, 2003. View at Publisher · View at Google Scholar · View at Scopus
  15. D. Basu, I. Lopez, A. Kulkarni, and J. H. Sellin, “Impact of race and ethnicity on inflammatory bowel disease,” American Journal of Gastroenterology, vol. 100, no. 10, pp. 2254–2261, 2005. View at Publisher · View at Google Scholar · View at Scopus
  16. N. Tozun, O. Atug, N. Imeryuz et al., “Clinical characteristics of inflammatory bowel disease in Turkey: a multicenter epidemiologic survey,” Journal of Clinical Gastroenterology, vol. 43, no. 1, pp. 51–57, 2009. View at Publisher · View at Google Scholar · View at Scopus
  17. H. Abdul-Baki, I. ElHajj, L. M. N. El-Zahabi et al., “Clinical epidemiology of inflammatory bowel disease in Lebanon,” Inflammatory Bowel Diseases, vol. 13, no. 4, pp. 475–480, 2007. View at Publisher · View at Google Scholar · View at Scopus
  18. M. I. El Mouzan, A. M. Abdullah, and M. T. Al Habbal, “Epidemiology of juvenile-onset inflammatory bowel disease in Central Saudi Arabia,” Journal of Tropical Pediatrics, vol. 52, no. 1, pp. 69–71, 2006. View at Publisher · View at Google Scholar · View at Scopus
  19. C.-H. Tsai, H.-L. Chen, Y.-H. Ni et al., “Characteristics and trends in incidence of inflammatory bowel disease in Taiwanese children,” Journal of the Formosan Medical Association, vol. 103, no. 9, pp. 685–691, 2004. View at Scopus
  20. S. C. Ng, W. Tang, J. Ching, et al., “Incidence and phenotype of inflammatory bowel disease based on results from the Asia-Pacific crohn's and colitis epidemiology study,” Gastroenterology, vol. 145, no. 1, pp. 158–165, 2013.
  21. V. Pinsk, D. A. Lemberg, K. Grewal, C. C. Barker, R. A. Schreiber, and K. Jacobson, “Inflammatory bowel disease in the South Asian pediatric population of British Columbia,” American Journal of Gastroenterology, vol. 102, no. 5, pp. 1077–1083, 2007. View at Publisher · View at Google Scholar · View at Scopus
  22. K. Geboes, J.-F. Colombel, A. Greenstein et al., “Indeterminate colitis: a review of the concept—what's in a name?” Inflammatory Bowel Diseases, vol. 14, no. 6, pp. 850–857, 2008. View at Publisher · View at Google Scholar · View at Scopus
  23. E. Jan Irvine, F. Farrokhyar, and E. T. Swarbrick, “A critical review of epidemiological studies in inflammatory bowel disease,” Scandinavian Journal of Gastroenterology, vol. 36, no. 1, pp. 2–15, 2001. View at Scopus
  24. E. I. Benchimol, K. J. Fortinsky, P. Gozdyra, M. Van Den Heuvel, J. Van Limbergen, and A. M. Griffiths, “Epidemiology of pediatric inflammatory bowel disease: a systematic review of international trends,” Inflammatory Bowel Diseases, vol. 17, no. 1, pp. 423–439, 2011. View at Publisher · View at Google Scholar · View at Scopus
  25. D. C. Baumgart, C. N. Bernstein, Z. Abbas et al., “IBD around the world: comparing the epidemiology, diagnosis, and treatment: proceedings of the World Digestive Health Day 2010—inflammatory bowel disease task force meeting,” Inflammatory Bowel Diseases, vol. 17, no. 2, pp. 639–644, 2011. View at Publisher · View at Google Scholar · View at Scopus
  26. J. Cosnes, S. Cattan, A. Blain et al., “Long-term evolution of disease behavior of Crohn's disease,” Inflammatory Bowel Diseases, vol. 8, no. 4, pp. 244–250, 2002. View at Scopus
  27. N. A. Molodecky, I. S. Soon, D. M. Rabi et al., “Increasing incidence and prevalence of the inflammatory bowel diseases with time, based on systematic review,” Gastroenterology, vol. 142, no. 1, pp. 46.e42–54.e42, 2012. View at Publisher · View at Google Scholar · View at Scopus
  28. M. Ravikumara and B. K. Sandhu, “Epidemiology of inflammatory bowel diseases in childhood,” Indian Journal of Pediatrics, vol. 73, no. 8, pp. 717–721, 2006. View at Publisher · View at Google Scholar · View at Scopus
  29. A. M. Leichtner and L. Higuchi, “Epidemiology of ulcerative colitis,” in Pediatric Gastrointestinal Disease, O.-J. Goulet, R. Kleinman, P. Sherman, et al., Eds., p. 826, BC Decker International, 2004.
  30. A. Bousvaros, F. Sylvester, S. Kugathasan et al., “Challenges in pediatric inflammatory bowel disease,” Inflammatory Bowel Diseases, vol. 12, no. 9, pp. 885–913, 2006. View at Publisher · View at Google Scholar · View at Scopus
  31. S. C. Ng, C. N. Bernstein, M. H. Vatn et al., “Epidemiology and Natural History Task Force of the International Organization of Inflammatory Bowel Disease (IOIBD). Geographical variability and environmental risk factors in inflammatory bowel disease,” Gut, vol. 62, no. 4, pp. 630–649, 2013.
  32. G. Guariso, M. Gasparetto, L. Visonà Dalla Pozza et al., “Inflammatory bowel disease developing in paediatric and adult age,” Journal of Pediatric Gastroenterology and Nutrition, vol. 51, no. 6, pp. 698–707, 2010. View at Publisher · View at Google Scholar · View at Scopus
  33. C. N. Bernstein, “New insights into ibd epidemiology: are there any lessons for treatment?” Digestive Diseases, vol. 28, no. 3, pp. 406–410, 2010. View at Publisher · View at Google Scholar · View at Scopus
  34. M. B. Heyman, B. S. Kirschner, B. D. Gold et al., “Children with early-onset inflammatory bowel disease (IBD): analysis of a pediatric IBD consortium registry,” Journal of Pediatrics, vol. 146, no. 1, pp. 35–40, 2005. View at Publisher · View at Google Scholar · View at Scopus
  35. A. Merchant, “Inflammatory bowel disease in children: an overview for pediatric healthcare providers,” Gastroenterology Nursing, vol. 30, no. 4, pp. 278–282, 2007. View at Publisher · View at Google Scholar · View at Scopus
  36. P. Mamula, G. W. Telega, J. E. Markowitz et al., “Inflammatory bowel disease in children 5 years of age and younger,” American Journal of Gastroenterology, vol. 97, no. 8, pp. 2005–2010, 2002. View at Publisher · View at Google Scholar · View at Scopus
  37. G. Marx, E. G. Seidman, S. R. Martin, and C. Deslandres, “Outcome of Crohn's disease diagnosed before two years of age,” Journal of Pediatrics, vol. 140, no. 4, pp. 470–473, 2002. View at Publisher · View at Google Scholar · View at Scopus
  38. J. D. Gryboski, “Crohn's disease in children 10 years old and younger: comparison with ulcerative colitis,” Journal of Pediatric Gastroenterology and Nutrition, vol. 18, no. 2, pp. 174–182, 1994. View at Scopus
  39. D. Kotlarz, R. Beier, D. Murugan et al., “Loss of interleukin-10 signaling and infantile inflammatory bowel disease: implications for diagnosis and therapy,” Gastroenterology, vol. 143, no. 2, pp. 347–355, 2012.
  40. B. Begue, J. Verdier, F. Rieux-Laucat et al., “Defective IL10 signaling defining a subgroup of patients with inflammatory bowel disease,” American Journal of Gastroenterology, vol. 106, no. 8, pp. 1544–1555, 2011. View at Publisher · View at Google Scholar · View at Scopus
  41. E.-O. Glocker, D. Kotlarz, K. Boztug et al., “Inflammatory bowel disease and mutations affecting the interleukin-10 receptor,” The New England Journal of Medicine, vol. 361, no. 21, pp. 2033–2045, 2009. View at Publisher · View at Google Scholar · View at Scopus
  42. K. R. Engelhardt, N. Shah, I. Faizura-Yeop, et al., “Clinical outcome in IL-10- and IL-10 receptor-deficient patients with or without hematopoietic stem cell transplantation,” Journal of Allergy and Clinical Immunology, vol. 131, no. 3, pp. 825–830, 2013.
  43. A. M. Griffiths and J. P. Hugot, “Epidemiology of crohn disease,” in Pediatric Gastrointestinal Disease, O.-J. Goulet, R. Kleinman, P. Sherman, et al., Eds., pp. 789–790, BC Decker International, 2004.
  44. J. Cosnes, C. Gowerrousseau, P. Seksik, and A. Cortot, “Epidemiology and natural history of inflammatory bowel diseases,” Gastroenterology, vol. 140, no. 6, pp. 1785–1794, 2011. View at Publisher · View at Google Scholar · View at Scopus
  45. P. Lehtinen, M. Ashorn, S. Iltanen et al., “Incidence trends of pediatric inflammatory bowel disease in Finland, 1987––2003, a nationwide study,” Inflammatory Bowel Diseases, vol. 17, no. 8, pp. 1778–1783, 2011. View at Publisher · View at Google Scholar · View at Scopus
  46. R. N. Baldassano and D. A. Piccoli, “Inflammatory bowel disease in pediatric and adolescent patients,” Gastroenterology Clinics of North America, vol. 28, no. 2, pp. 445–458, 1999. View at Publisher · View at Google Scholar · View at Scopus
  47. C. Gower-Rousseau, F. Vasseur, M. Fumery, et al., “Epidemiology of inflammatory bowel diseases: new insights from a French population-based registry (EPIMAD),” Digestive and Liver Disease, vol. 45, no. 2, pp. 89–94, 2013.
  48. C. N. Bernstein, A. Wajda, L. W. Svenson et al., “The epidemiology of inflammatory bowel disease in Canada: a population-based study,” American Journal of Gastroenterology, vol. 101, no. 7, pp. 1559–1568, 2006. View at Publisher · View at Google Scholar · View at Scopus
  49. M. D. Kappelman, K. R. Moore, J. K. Allen, and S. F. Cook, “Recent trends in the prevalence of Crohn’s Disease and ulcerative colitis in a commercially insured US population,” Digestive Diseases and Sciences, vol. 58, no. 2, pp. 519–525, 2013.
  50. O. M. Damas, D. A. Jahann, R. Reznik et al., “Phenotypic manifestations of inflammatory bowel disease differ between Hispanics and non-Hispanic whites: results of a large cohort study,” The American Journal of Gastroenterology, vol. 108, no. 2, pp. 231–239, 2013.
  51. V. Sdepanian, “Inflammatory bowel disease in the developing world, is it different?” in Proceedings of the 4th World Congress of Pediatric Gastroenterology, Hepatology and Nutrition, Taipei, Taiwan, November 2012.
  52. J. Zhao, S. C. Ng, Y. Lei et al., “First prospective, population-based inflammatory bowel disease incidence study in Mainland of China: the emergence of, ‘Western disease’,” Inflammatory Bowel Diseases, vol. 19, no. 9, pp. 1839–1845, 2013.
  53. M. D. Pfefferkorn, F. E. Marshalleck, S. A. Saeed, J. B. Slpawski, B. C. Lindeln, and B. F. Weston, “NASPGHAN clinical report on the evaluation and treatment of pediatric patients with internal penetrating Crohn’s disease: intraabdominal abscess with and without fistula,” Journal of Pediatric Gastroenterology and Nutrition, vol. 57, no. 3, pp. 394–400, 2013.
  54. G. Vernier-Massouille, M. Balde, J. Salleron et al., “Natural history of pediatric Crohn's disease: a population-based cohort study,” Gastroenterology, vol. 135, no. 4, pp. 1106–1113, 2008. View at Publisher · View at Google Scholar · View at Scopus
  55. J. Markowitz, “Natural history of pediatric Crohn disease,” in Pediatric Inflammatory Bowel Disease, P. Mamula, J. E. Markowitz, and R. N. Baldassano, Eds., pp. 67–72, Springer, New York, NY, USA, 2008.
  56. J. S. Hyams, “Natural history of pediatric ulcerative colitis,” in Pediatric Inflammatory Bowel Diseases, P. Mamula, J. E. Markowitz, and R. N. Baldassano, Eds., pp. 75–79, Springer, New York, NY, USA, 2008.
  57. T. O. Falaiye, K. R. Mitchell, Z. Lu et al., “Outcome following infliximab therapy for pediatric patients hospitalized with refractory colitis-predominant inflammatory Bowel disease,” Journal of Pediatric Gastroenterology and Nutrition. In press.
  58. C. Gower-Rousseau, L. Dauchet, G. Vernier-Massouille et al., “The natural history of pediatric ulcerative colitis: a population-based cohort study,” American Journal of Gastroenterology, vol. 104, no. 8, pp. 2080–2088, 2009. View at Publisher · View at Google Scholar · View at Scopus