Review Article
Alterations of Blood-Brain Barrier and Associated Factors in Acute Liver Failure
Table 1
Different studies on BBB penetration by different compounds in ALF.
| Study | ALF model | Tracer for BBB permeability | Results |
| Dixit and Chang [24] | D-galactosamine induced ALF rats | Trypan blue | + | Laursen et al. [22] | PCA rats | HRP | + | Zaki et al. [26] | PCA rats | Amino acid | + | Horowitz et al. [27] | Galactosamine-induced ALF rats | Aminoisobutyric acid | + | Lv et al. [12] | D-galactosamine/liposaccharide | Evans blue | + | Chavarria et al. [28] | PCA rats |
14C-labeled sucrose | − | Sarna et al. [29] | PCA rats | Amino acid | − | Alexander et al. [30] | Portacaval shunting rats | Labelled mannitol and amino acids | − | Ahl et al. [33] | Patients | Ammonia | + | Lockwood et al. [34] | Patients | Ammonia | + | Sørensen and Keiding [35] | Patients | Ammonia | + | Goldbecker et al. [32] | Patients | Ammonia | − |
|
|
PCA: a model which mimics the condition of portal-systemic shunting in patients with liver cirrhosis.
|