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Gastroenterology Research and Practice
Volume 2013 (2013), Article ID 924769, 8 pages
http://dx.doi.org/10.1155/2013/924769
Research Article

Effect of Di(2-ethylhexyl)phthalate on Helicobacter pylori-Induced Apoptosis in AGS Cells

1Department of Physiology, College of Medicine, Kaohsiung Medical University, Kaohsiung City 807, Taiwan
2Department of Pediatrics, E-Da Hospital, Kaohsiung City 824, Taiwan
3School of Pharmacy, Kaohsiung Medical University, Kaohsiung City 807, Taiwan
4Department of Medical Imaging, Kaohsiung Medical University Hospital, Kaohsiung City 807, Taiwan
5Department of Nutritional Sciences, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan
6Division of Gastroenterology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung City 807, Taiwan
7Department of Medicine, Faculty of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung City 807, Taiwan
8Department of Internal Medicine, Kaohsiung Municipal Hsiao-Kang Hospital, Kaohsiung City 812, Taiwan
9Cancer Center, Kaohsiung Medical University Hospital, Kaohsiung City 807, Taiwan
10Graduate Institute of Public Health, Kaohsiung Medical University, Kaohsiung City 807, Taiwan
11Department of Obstetrics and Gynecology, E-Da Hospital, Kaohsiung 824, Taiwan
12School of Medicine, College of Medicine, I-Shou University, Kaohsiung City 840, Taiwan

Received 19 July 2013; Accepted 31 October 2013

Academic Editor: Lin-Li Chang

Copyright © 2013 Chuang-Hao Lin et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. S. Sathyanarayana, “Phthalates and Children's Health,” Current Problems in Pediatric and Adolescent Health Care, vol. 38, no. 2, pp. 34–49, 2008. View at Publisher · View at Google Scholar · View at Scopus
  2. R. Kavlock, K. Boekelheide, R. Chapin, et al., “NTP center for the evaluation of risks to human reproduction: phthalates expert panel report on the reproductive and developmental toxicity of di(2-ethylhexyl) phthalate,” Reproductive Toxicology, vol. 16, no. 5, pp. 529–653, 2002. View at Publisher · View at Google Scholar · View at Scopus
  3. J. J. Adibi, F. P. Perera, W. Jedrychowski et al., “Prenatal exposures to Phthalates among women in New York and Krakow, Poland,” Environmental Health Perspectives, vol. 111, no. 14, pp. 1719–1722, 2003. View at Scopus
  4. T. Schettler, “Human exposure to phthalates via consumer products,” International Journal of Andrology, vol. 29, no. 1, pp. 134–139, 2006. View at Publisher · View at Google Scholar · View at Scopus
  5. G. Latini, C. de Felice, G. Presta et al., “In utero exposure to di-(2-ethylhexyl)phthalate and duration of human pregnancy,” Environmental Health Perspectives, vol. 111, no. 14, pp. 1783–1785, 2003. View at Scopus
  6. R. M. Whyatt, J. J. Adibi, A. M. Calafat et al., “Prenatal di(2-ethylhexyl)phthalate exposure and length of gestation among an inner-city cohort,” Pediatrics, vol. 124, no. 6, pp. e1213–e1220, 2009. View at Publisher · View at Google Scholar · View at Scopus
  7. Y. Suzuki, M. Niwa, J. Yoshinaga, Y. Mizumoto, S. Serizawa, and H. Shiraishi, “Prenatal exposure to phthalate esters and PAHs and birth outcomes,” Environment International, vol. 36, no. 7, pp. 699–704, 2010. View at Publisher · View at Google Scholar · View at Scopus
  8. J. G. Kusters, A. H. M. van Vliet, and E. J. Kuipers, “Pathogenesis of Helicobacter pylori infection,” Clinical Microbiology Reviews, vol. 19, no. 3, pp. 449–490, 2006. View at Publisher · View at Google Scholar · View at Scopus
  9. S. M. Kelly, M. C. L. Pitcher, S. M. Farmery, and G. R. Gibson, “Isolation of Helicobacter pylori from feces of patients with dyspepsia in the United Kingdom,” Gastroenterology, vol. 107, no. 6, pp. 1671–1674, 1994. View at Scopus
  10. S. F. Moss, J. Calam, B. Agarwal, S. Wang, and P. R. Holt, “Induction of gastric epithelial apoptosis by Helicobacter pylori,” Gut, vol. 38, no. 4, pp. 498–501, 1996. View at Scopus
  11. F. Kacar, I. Meteoǧlu, H. Yasa, and E. Levi, “Helicobacter pylori-induced changes in the gastric mucosa are associated with mitogen-activated protein kinase (MAPK) activation,” Applied Immunohistochemistry and Molecular Morphology, vol. 15, no. 2, pp. 224–228, 2007. View at Publisher · View at Google Scholar · View at Scopus
  12. G. Chen, E. M. Sordillo, W. G. Ramey et al., “Apoptosis in gastric epithelial cells is induced by Helicobacter pylori and accompanied by increased expression of BAK,” Biochemical and Biophysical Research Communications, vol. 239, no. 2, pp. 626–632, 1997. View at Publisher · View at Google Scholar · View at Scopus
  13. S. H. Chu, J. W. Lim, K. H. Kim, and H. Kim, “NF-κB and Bcl-2 in Helicobacter pylori—induced apoptosis in gastric epithelial cells,” Annals of the New York Academy of Sciences, vol. 1010, pp. 568–572, 2003. View at Publisher · View at Google Scholar · View at Scopus
  14. I. J. Choi, J. S. Kim, J. M. Kim, H. C. Jung, and I. S. Song, “Effect of inhibition of extracellular signal-regulated kinase 1 and 2 pathway on apoptosis and bcl-2 expression in Helicobacter pylori-infected AGS cells,” Infection and Immunity, vol. 71, no. 2, pp. 830–837, 2003. View at Publisher · View at Google Scholar · View at Scopus
  15. M.-L. Chen, J.-S. Chen, C.-L. Tang, and I.-F. Mao, “The internal exposure of Taiwanese to phthalate—an evidence of intensive use of plastic materials,” Environment International, vol. 34, no. 1, pp. 79–85, 2008. View at Publisher · View at Google Scholar · View at Scopus
  16. P.-C. Huang, P.-L. Kuo, Y.-L. Guo, P.-C. Liao, and C.-C. Lee, “Associations between urinary phthalate monoesters and thyroid hormones in pregnant women,” Human Reproduction, vol. 22, no. 10, pp. 2715–2722, 2007. View at Publisher · View at Google Scholar · View at Scopus
  17. J.-T. Lin, J.-T. Wang, T.-H. Wang, M.-S. Wu, T.-K. Lee, and C.-J. Chen, “Helicobacter pylori infection in a randomly selected population, healthy volunteers, and patients with gastric ulcer and gastric adenocarcinoma. A seroprevalence study in Taiwan,” Scandinavian Journal of Gastroenterology, vol. 28, no. 12, pp. 1067–1072, 1993. View at Scopus
  18. L. J. Murray, E. E. McCrum, A. E. Evans, and K. B. Bamford, “Epidemiology of Helicobacter pylori infection among 4742 randomly selected subjects from Northern Ireland,” International Journal of Epidemiology, vol. 26, no. 4, pp. 880–887, 1997. View at Publisher · View at Google Scholar · View at Scopus
  19. S. Wagner, W. Beil, J. Westermann et al., “Regulation of gastric epithelial cell growth by Helicobacter pylori: evidence for a major role of apoptosis,” Gastroenterology, vol. 113, no. 6, pp. 1836–1847, 1997. View at Scopus
  20. B. J. Marshall and J. R. Warren, “Unidentified curved bacilli in the stomach of patients with gastritis and peptic ulceration,” The Lancet, vol. 1, no. 8390, pp. 1311–1315, 1984. View at Scopus
  21. “NIH Consensus Conference. Helicobacter pylori in peptic ulcer disease. NIH Consensus Development Panel on Helicobacter pylori in Peptic Ulcer Disease,” The Journal of the American Medical Association, vol. 272, no. 1, pp. 65–69, 1994. View at Publisher · View at Google Scholar
  22. M. Sharman, W. A. Read, L. Castle, and J. Gilbert, “Levels of di-(2-ethylhexyl)phthalate and total phthalate esters in milk, cream, butter and cheese,” Food Additives and Contaminants, vol. 11, no. 3, pp. 375–385, 1994. View at Scopus
  23. J. H. Petersent and T. Breindahl, “Plasticizers in total diet samples, baby food and infant formulae,” Food Additives and Contaminants, vol. 17, no. 2, pp. 133–141, 2000. View at Scopus
  24. T. Cirillo, E. Fasano, E. Castaldi, P. Montuori, and R. Amodio Cocchieri, “Children's exposure to Di(2-ethylhexyl)phthalate and dibutylphthalate plasticizers from school meals,” Journal of Agricultural and Food Chemistry, vol. 59, no. 19, pp. 10532–10538, 2011. View at Publisher · View at Google Scholar · View at Scopus
  25. C. J. Hines, N. B. N. Hopf, J. A. Deddens, M. J. Silva, and A. M. Calafat, “Estimated daily intake of phthalates in occupationally exposed groups,” Journal of Exposure Science and Environmental Epidemiology, vol. 21, no. 2, pp. 133–141, 2011. View at Publisher · View at Google Scholar · View at Scopus
  26. M. Wittassek and J. Angerer, “Phthalates: metabolism and exposure,” International Journal of Andrology, vol. 31, no. 2, pp. 131–138, 2008. View at Publisher · View at Google Scholar · View at Scopus
  27. CPCS. U.S. Consumer Product Safety Commission.Toxicity Reviews of Di-(2-Ethylhexyl) Phthalate (DEHP), vol. 51, 2010.
  28. N. C. T. van Grieken, G. A. Meijer, A. Zur Hausen, S. G. M. Meuwissen, J. P. A. Baak, and E. J. Kuipers, “Increased apoptosis in gastric mucosa adjacent to intestinal metaplasia,” Journal of Clinical Pathology, vol. 56, no. 5, pp. 358–362, 2003. View at Publisher · View at Google Scholar · View at Scopus
  29. H. H.-X. Xia and N. J. Talley, “Apoptosis in gastric epithelium induced by Helicobacter pylori infection: implications in gastric carcinogenesis,” American Journal of Gastroenterology, vol. 96, no. 1, pp. 16–26, 2001. View at Publisher · View at Google Scholar · View at Scopus
  30. S. Tiwari, U. Ghoshal, U. C. Ghoshal et al., “Helicobacter pylori-induced apoptosis in pathogenesis of gastric carcinoma,” Indian Journal of Gastroenterology, vol. 24, no. 5, pp. 193–196, 2005. View at Scopus
  31. T. Guo, J.-M. Qian, J.-Z. Zhang, X.-B. Li, and Y.-Q. Zhao, “Effects of Helicobacter pylori and Helicobacter pylori-related cytokines on apoptosis of gastric epithelial cells and mechanisms thereof,” National Medical Journal of China, vol. 86, no. 38, pp. 2670–2673, 2006. View at Scopus
  32. Z.-F. Liu, C.-Y. Chen, W. Tang, J.-Y. Zhang, Y.-Q. Gong, and J.-H. Jia, “Gene-expression profiles in gastric epithelial cells stimulated with spiral and coccoid Helicobacter pylori,” Journal of Medical Microbiology, vol. 55, no. 8, pp. 1009–1015, 2006. View at Publisher · View at Google Scholar · View at Scopus
  33. K.-M. Kim, S.-G. Lee, J.-M. Kim et al., “Helicobacter pylori γ-glutamyltranspeptidase induces cell cycle arrest at the G1-S phase transition,” The Journal of Microbiology, vol. 48, no. 3, pp. 372–377, 2010. View at Publisher · View at Google Scholar · View at Scopus
  34. G. K. Anagnostopoulos, D. Stefanou, E. Arkoumani et al., “Bax and Bcl-2 protein expression in gastric precancerous lesions: immunohistochemical study,” Journal of Gastroenterology and Hepatology, vol. 20, no. 11, pp. 1674–1678, 2005. View at Publisher · View at Google Scholar · View at Scopus
  35. F. Bir, N. Calli-Demirkan, A. C. Tufan, M. Akbulut, and N. L. Satiroglu-Tufan, “Apoptotic cell death and its relationship to gastric carcinogenesis,” World Journal of Gastroenterology, vol. 13, no. 23, pp. 3183–3188, 2007. View at Scopus
  36. H.-F. Liu, W.-W. Liu, G.-A. Wang, and X.-C. Teng, “Effect of Helicobacter pylori infection on Bax protein expression in patients with gastric precancerous lesions,” World Journal of Gastroenterology, vol. 11, no. 37, pp. 5899–5901, 2005. View at Scopus
  37. M. Gryko, A. Pryczynicz, K. Guzinska-Ustymowicz, et al., “Immunohistochemical assessment of apoptosis-associated proteins: p53, Bcl-xL, Bax and Bak in gastric cancer cells in correlation with clinical and pathomorphological factors,” Advances in Medical Sciences, vol. 57, no. 1, pp. 77–83, 2012.
  38. R. C. Budd, W.-C. Yeh, and J. Tschopp, “cFLIP regulation of lymphocyte activation and development,” Nature Reviews Immunology, vol. 6, no. 3, pp. 196–204, 2006. View at Publisher · View at Google Scholar · View at Scopus
  39. R. J. Youle and A. Strasser, “The BCL-2 protein family: opposing activities that mediate cell death,” Nature Reviews Molecular Cell Biology, vol. 9, no. 1, pp. 47–59, 2008. View at Publisher · View at Google Scholar · View at Scopus
  40. J. Rudi, D. Kuck, S. Strand et al., “Involvement of the CD95 (APO-1/Fas) receptor and ligand system in Helicobacter pylori-induced gastric epithelial apoptosis,” Journal of Clinical Investigation, vol. 102, no. 8, pp. 1506–1514, 1998. View at Scopus
  41. S. Maeda, H. Yoshida, Y. Mitsuno et al., “Analysis of apoptotic and antiapoptotic signalling pathways induced by Helicobacter pylori,” Gut, vol. 50, no. 6, pp. 771–778, 2002. View at Publisher · View at Google Scholar · View at Scopus
  42. M. Mukai, T. Kusama, Y. Hamanaka et al., “Cross talk between apoptosis and invasion signaling in cancer cells through caspase-3 activation,” Cancer Research, vol. 65, no. 20, pp. 9121–9125, 2005. View at Publisher · View at Google Scholar · View at Scopus
  43. N. Isobe, H. Onodera, A. Mori et al., “Caspase-3 expression in human gastric carcinoma and its clinical significance,” Oncology, vol. 66, no. 3, pp. 201–209, 2004. View at Publisher · View at Google Scholar · View at Scopus
  44. H.-C. Zheng, J.-M. Sun, Z.-L. Wei, X.-F. Yang, Y.-C. Zhang, and Y. Xin, “Expression of Fas ligand and Caspase-3 contributes to formation of immune escape in gastric cancer,” World Journal of Gastroenterology, vol. 9, no. 7, pp. 1415–1420, 2003. View at Scopus
  45. S. Koyama, “Differential expression of intracellular apoptotic signaling molecules in tumor and tumor-infiltrating lymphocytes during development of invasion and/or metastasis of gastric carcinoma,” Digestive Diseases and Sciences, vol. 48, no. 12, pp. 2290–2300, 2003. View at Publisher · View at Google Scholar · View at Scopus