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Gastroenterology Research and Practice
Volume 2014 (2014), Article ID 293206, 6 pages
http://dx.doi.org/10.1155/2014/293206
Review Article

Gluten Sensitivity Presenting as a Neuropsychiatric Disorder

1Faculty of Medicine, University of Alberta, Edmonton, AB, Canada T6K 4C1
2Department of Family Medicine, University of Alberta, Edmonton, AB, Canada T6G 2C8

Received 20 October 2013; Revised 25 December 2013; Accepted 2 January 2014; Published 12 February 2014

Academic Editor: R. Eliakim

Copyright © 2014 Stephen J. Genuis and Rebecca A. Lobo. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. M. Hadjivassiliou, A. Gibson, G. A. Davies-Jones, A. J. Lobo, T. J. Stephenson, and A. Milford-Ward, “Does cryptic gluten sensitivity play a part in neurological illness?” The Lancet, vol. 347, no. 8998, pp. 369–371, 1996. View at Publisher · View at Google Scholar · View at Scopus
  2. M. Hadjivassiliou, D. S. Sanders, R. A. Grünewald, N. Woodroofe, S. Boscolo, and D. Aeschlimann, “Gluten sensitivity: from gut to brain,” The Lancet Neurology, vol. 9, no. 3, pp. 318–330, 2010. View at Publisher · View at Google Scholar · View at Scopus
  3. K. Burk, S. Bösch, C. A. Müller et al., “Sporadic cerebellar ataxia associated with gluten sensitivity,” Brain, vol. 124, no. 5, pp. 1013–1019, 2001. View at Scopus
  4. F. Dickerson, C. Stallings, A. Origoni et al., “Markers of gluten sensitivity and celiac disease in recent-onset psychosis and multi-episode schizophrenia,” Biological Psychiatry, vol. 68, no. 1, pp. 100–104, 2010. View at Publisher · View at Google Scholar · View at Scopus
  5. F. Dickerson, C. Stallings, A. Origoni, C. Vaughan, S. Khushalani, and R. Yolken, “Markers of gluten sensitivity in acute mania: a longitudinal study,” Psychiatry Research, vol. 196, no. 1, pp. 68–71, 2012. View at Publisher · View at Google Scholar · View at Scopus
  6. K. Rostami and S. Hogg-Kollars, “A patient's journey. Non-coeliac gluten sensitivity,” British Medical Journal, vol. 345, Article ID e7982, 2012. View at Publisher · View at Google Scholar
  7. A. Morant, “Psychosis and silent celiac disease in a down syndrome adolescent: a case report,” Case Reports in Pediatrics, vol. 2011, Article ID 970143, 3 pages, 2011. View at Publisher · View at Google Scholar
  8. J. Serratrice, P. Disdier, A. Kaladjian et al., “Psychosis revealing a silent celiac disease in a young women with trisomy 21,” Presse Medicale, vol. 31, no. 33, pp. 1551–1553, 2002. View at Scopus
  9. M. M. Singh and S. R. Kay, “Wheat gluten as a pathogenic factor in schizophrenia,” Science, vol. 191, no. 4225, pp. 401–402, 1976. View at Scopus
  10. A. de Santis, G. Addolorato, A. Romito et al., “Schizophrenic symptoms and SPECT abnormalities in a coeliac patient: regression after a gluten-free diet,” Journal of Internal Medicine, vol. 242, no. 5, pp. 421–423, 1997. View at Scopus
  11. M. Hadjivassiliou, R. H. Kandler, A. K. Chattopadhyay et al., “Dietary treatment of gluten neuropathy,” Muscle and Nerve, vol. 34, no. 6, pp. 762–766, 2006. View at Publisher · View at Google Scholar · View at Scopus
  12. P. Canales, V. P. Mery, F. J. Larrondo, F. L. Bravo, and J. Godoy, “Epilepsy and celiac disease: favorable outcome with a gluten-free diet in a patient refractory to antiepileptic drugs,” Neurologist, vol. 12, no. 6, pp. 318–321, 2006. View at Publisher · View at Google Scholar · View at Scopus
  13. S. J. Genuis and T. P. Bouchard, “Celiac disease presenting as autism,” Journal of Child Neurology, vol. 25, no. 1, pp. 114–119, 2010. View at Publisher · View at Google Scholar · View at Scopus
  14. N. K. Goel, R. D. McBane, and P. S. Kamath, “Cardiomyopathy associated with celiac disease,” Mayo Clinic Proceedings, vol. 80, no. 5, pp. 674–676, 2005. View at Scopus
  15. R. Rajput and S. Chatterjee, “Primary infertility as a rare presentation of celiac disease,” Fertility and Sterility, vol. 94, no. 7, pp. 2771.e5–2771.e7, 2010. View at Publisher · View at Google Scholar · View at Scopus
  16. V. Hyrailles, D. Desprez, L. Beauerère et al., “Uveitis complicating celiac disease and cured by gluten-free diet,” Gastroenterologie Clinique et Biologique, vol. 19, no. 5, pp. 543–544, 1995. View at Scopus
  17. C. C. Pereira, P. H. S. Corrêa, and A. Halpern, “Case report: recently diagnosed celiac disease as aggravating factor of osteoporosis in old woman,” Arquivos Brasileiros de Endocrinologia e Metabologia, vol. 50, no. 6, pp. 1127–1132, 2006. View at Publisher · View at Google Scholar · View at Scopus
  18. I. Aziz and D. S. Sanders, “Emerging concepts: from coeliac disease to non-coeliac gluten sensitivity,” The Proceedings of the Nutrition Society, vol. 71, pp. 576–580, 2012.
  19. A. Carroccio, P. Mansueto, G. Iacono, et al., “Non-celiac wheat sensitivity diagnosed by double-blind placebo-controlled challenge: exploring a new clinical entity,” The American Journal of Gastroenterology, vol. 107, pp. 1898–1906, 2012.
  20. D. E. Loft, C. U. Nwokolo, and P. J. Ciclitira, “The diagnosis of gluten sensitivity and coeliac diseas—the two are not mutually inclusive,” European Journal of Gastroenterology and Hepatology, vol. 10, no. 11, pp. 911–913, 1998. View at Scopus
  21. J. Brostoff and L. Gamlin, Food Allergies and Food InTolerance: The Complete Guide to Their Identification and Treatment, Inner Traditions International, Rochester, NY, USA, 2000.
  22. J. R. Biesiekierski, E. D. Newnham, P. M. Irving et al., “Gluten causes gastrointestinal symptoms in subjects without celiac disease: a double-blind randomized placebo-controlled trial,” The American Journal of Gastroenterology, vol. 106, no. 3, pp. 508–514, 2011. View at Publisher · View at Google Scholar · View at Scopus
  23. A. Sapone, J. C. Bai, C. Ciacci et al., “Spectrum of gluten-related disorders: consensus on new nomenclature and classification,” BMC Medicine, vol. 10, article 13, 2012. View at Publisher · View at Google Scholar · View at Scopus
  24. Enterolab, “Specialized Laboratory Testing for Optimal Intestinal and Overall Health,” 2013, https://www.enterolab.com/Default.aspx.
  25. M. Kappler, S. Krauss-Etschmann, V. Diehl, H. Zeilhofer, and S. Koletzko, “Detection of secretory IgA antibodies against gliadin and human tissue transglutaminase in stool to screen for coeliac disease in children: validation study,” British Medical Journal, vol. 332, no. 7535, pp. 213–214, 2006. View at Publisher · View at Google Scholar · View at Scopus
  26. M. Brottveit, P. O. Vandvik, S. Wojniusz, A. Lovik, K. E. Lundin, and B. Boye, “Absence of somatization in non-coeliac gluten sensitivity,” Scandinavian Journal of Gastroenterology, vol. 47, pp. 770–777, 2012.
  27. British Medical Journal, Poll Archive. Polls in 2012, http://www.bmj.com/about-bmj/poll-archive.
  28. I. Aziz, M. Hadjivassiliou, and D. S. Sanders, “Does gluten sensitivity in the absence of coeliac disease exist?” British Medical Journal, vol. 345, Article ID e7907, 2012.
  29. J. R. Biesiekierski, S. L. Peters, E. D. Newnham, O. Rosella, J. G. Muir, and P. R. Gibson, “No effects of gluten in patients with self-reported non-celiac gluten sensitivity after dietary reduction of fermentable, poorly absorbed, short-chain carbohydrates,” Gastroenterology, vol. 145, no. 2, pp. 320–328, 2013. View at Publisher · View at Google Scholar
  30. I. Mascord, D. Freed, and B. Durrant, “Antibodies to foodstuffs in schizophrenia,” British Medical Journal, vol. 1, no. 6123, p. 1351, 1978. View at Scopus
  31. H. G. Kinnell, E. Kirkwood, and C. Lewis, “Food antibodies in schizophrenia,” Psychological Medicine, vol. 12, no. 1, pp. 85–89, 1982. View at Scopus
  32. A. Ashkenazi, D. Krasilowsky, and S. Levin, “Immunologic reaction of psychotic patients to fractions of gluten,” The American Journal of Psychiatry, vol. 136, no. 10, pp. 1306–1309, 1979. View at Scopus
  33. K. L. Reichelt and J. Landmark, “Specific IgA antibody increases in schizophrenia,” Biological Psychiatry, vol. 37, no. 6, pp. 410–413, 1995. View at Publisher · View at Google Scholar · View at Scopus
  34. I. Wilke, V. Arolt, M. Rothermundt, C. Weitzsch, M. Hornberg, and H. Kirchner, “Investigations of cytokine production in whole blood cultures of paranoid and residual schizophrenic patients,” European Archives of Psychiatry and Clinical Neuroscience, vol. 246, no. 5, pp. 279–284, 1996. View at Publisher · View at Google Scholar · View at Scopus
  35. J. Wei and G. P. Hemmings, “Gene, gut and schizophrenia: the meeting point for the gene-environment interaction in developing schizophrenia,” Medical Hypotheses, vol. 64, no. 3, pp. 547–552, 2005. View at Publisher · View at Google Scholar · View at Scopus
  36. S. J. Genuis, “Sensitivity-related illness: the escalating pandemic of allergy, food intolerance and chemical sensitivity,” Science of the Total Environment, vol. 408, no. 24, pp. 6047–6061, 2010. View at Publisher · View at Google Scholar · View at Scopus
  37. C. S. Miller, “Toxicant-induced loss of tolerance—an emerging theory of disease?” Environmental Health Perspectives, vol. 105, no. 2, pp. 445–453, 1997. View at Scopus
  38. N. Ashford and C. Miller, Chemical Exposures: Low Levels and High Stakes, John Wiley and Sons, New York, NY, USA, 2nd edition, 1998.
  39. S. J. Genuis and A. K. Siy, “Nutritional supplementation and dietary restriction in the resolution of enthesitis-related arthritis,” JRSM Short Reports, vol. 2, no. 4, p. 32, 2011. View at Publisher · View at Google Scholar
  40. M. L. Pall, “Multiple chemical sensitivity: toxicological questions and mechanisms,” in General and Applied Toxicology, B. Ballantyne, T. C. Marrs, and T. Syversen, Eds., chapter 20, John Wiley and Sons, London, UK, 3rd edition, 2009.
  41. M. L. Pall, Explaining “Unexplained Illness”: Disease Paradigm for Chronic Fatigue Syndrome, Multiple Chemical Sensitivity, Fibromyalgia, Post-Traumatic Stress Disorder, Gulf War Syndrome and Others, Harrington Park Press, New York, NY, USA, 2007.
  42. S. J. Genuis, “Chemical sensitivity: pathophysiology or pathopsychology?” Clinical Therapeutics, vol. 35, pp. 572–577, 2013.
  43. NHANES, “4th National Report on Exposure to Environmental Chemical Exposures,” 2012, http://www.cdc.gov/exposurereport/pdf/FourthReport.pdf.
  44. S. J. Genuis, “The chemical erosion of human health: adverse environmental exposure and in-utero pollution—determinants of congenital disorders and chronic disease,” Journal of Perinatal Medicine, vol. 34, no. 3, pp. 185–195, 2006. View at Publisher · View at Google Scholar · View at Scopus
  45. World Health Organization, “Sate of the Science of Endocrine Disrupting Chemicals 2012: Summary for Decision-Makers,” United Nations Environment Programme and the World Health Organization, 2013.
  46. T. Dantoft, J. Elberling, S. Brix, P. Szecsi, S. Vesterhauge, and S. Skovbjerg, “An elevated pro-inflammatory cytokine profile in un-exposed individuals with multiple chemical sensitivity,” Psychoneuroendocrinology, vol. 40, pp. 140–150, 2014.
  47. C. de Luca, M. G. Scordo, E. Cesareo et al., “Biological definition of multiple chemical sensitivity from redox state and cytokine profiling and not from polymorphisms of xenobiotic-metabolizing enzymes,” Toxicology and Applied Pharmacology, vol. 248, no. 3, pp. 285–292, 2010. View at Publisher · View at Google Scholar · View at Scopus
  48. S. J. Genuis, “The pandemic of idiopathic multimorbidity,” Canadian Family Physician. In press.
  49. M. R. Joffres, T. Williams, B. Sabo, and R. A. Fox, “Environmental sensitivities: prevalence of major symptoms in a referral center: the Nova Scotia environmental sensitivities research center study,” Environmental Health Perspectives, vol. 109, no. 2, pp. 161–165, 2001. View at Scopus
  50. C. Hausteiner, S. Bornschein, J. Hansen, T. Zilker, and H. Förstl, “Self-reported chemical sensitivity in Germany: a population-based survey,” International Journal of Hygiene and Environmental Health, vol. 208, no. 4, pp. 271–278, 2005. View at Publisher · View at Google Scholar · View at Scopus
  51. N. D. Berg, A. Linneberg, A. Dirksen, and J. Elberling, “Prevalence of self-reported symptoms and consequences related to inhalation of airborne chemicals in a Danish general population,” International Archives of Occupational and Environmental Health, vol. 81, no. 7, pp. 881–887, 2008. View at Publisher · View at Google Scholar · View at Scopus
  52. C. S. Miller and N. A. Ashford, “Multiple chemical intolerance and indoor air quality,” in Indoor Air Quality Handbook, J. D. Spengler, J. M. Samet, and J. F. McCarthy, Eds., chapter 27, MacGraw-Hill, New York, NY, USA, 2000.
  53. R. Vanga and D. A. Leffler, “Gluten sensitivity: not celiac and not certain,” Gastroenterology, vol. 145, pp. 276–279, 2013.