| Source | Study design | Parameters evaluated | Number of patients | Mean age | Study duration | Dosing regimen |
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Beaumont and Boeckxstaens (2009) [12] | DB, RCT crossover | Incidence of GER, acid reflux time | 27 | 54.0 | 12 d | T.i.d 20 mg | Cange et al. (2002) [13] | DB, RCT crossover | Incidence of acid GER, acid reflux time | 20 | 41.2 | 4 w | Q.d 40 mg |
Ciccaglione and Marzio (2003) [14] | DB, RCT | Incidence of GER, acid reflux time | 43 | 41.0 | 4 w | Q.i.d 10 mg | | DB, RCT | Incidence of GER, acid reflux time | 43 | 49.0 | 2 w | T.i.d | | 10, 10, 10 mg (D1–3) | Cossentino et al. (2012) [15] | 20, 10, 10 mg (D4) | | 20, 20, 10 mg (D5) | | 20, 20, 20 mg (D6–14) | Gerson et al. (2010) [16] | DB, RCT crossover | Incidence of GER, heartburn | 50 | 41.0 | 4 w | Q.d, 4 different doses | 10, 20, 40, 60 mg | Grossi et al. (2008) [17] | DB, RCT | Incidence of TLESR | 23 | 43.0 | 2 d | Q.i.d 10 mg | Lidums et al. (2000) [18] | DB, RCT | Incidence of GER, incidence of TLESR, acid reflux time, and rate of swallowing | 20 | 24.0 | 1 w | Q.2d 40 mg | Omari et al. (2006) [19] | DB, RCT1 | Incidence of TLESR, incidence of GER, gastric emptying, pharyngeal swallow, LES pressure, and acid reflux time | 30 | 10.0 | 12 h | A single dose 0.5 mg/kg |
van Herwaarden et al. (2002) [20] | DB, RCT crossover | Incidence of TLESR, incidence of GER, and acid reflux time | 37 | 42.3 | 4 days | Q.d 40 mg |
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