Clinical Study
The Relationship between H. pylori Infection and Osteoporosis in Japan
Table 1
Clinical characteristics
.
| | Male | Female | value | Total | | 95 (47.5)* | 105 (52.5)* | 200 (100)* |
| Patient profile | Age (years) | 62.8 (±7.7)** | 63.4 (±9.6)** | 0.637 | 63.1 (±8.8)** | BMI (kg/m2) | 23.6 (±2.6)** | 22.2 (±3.8)** | 0.002 | 22.9 (±3.4)** | Alcohol consumption | | | | | Nondrinker | 36 (37.9)* | 86 (81.9)* | <0.001 | 122 (61.0)* | Drinker | 59 (62.1)* | 19 (18.1)* | 78 (39.0)* | Smoking | | | | | Nonsmoker | 44 (46.3)* | 94 (89.5)* | <0.001 | 138 (69.0)* | Smoker | 51 (53.7)* | 11 (10.5)* | 62 (31.0)* |
| H. pylori infection status | H. pylori infection | | | | | Negative | 57 (60.0)* | 60 (57.1)* | 0.682 | 117 (58.5)* | Positive | 38 (40.0)* | 45 (42.9)* | 83 (41.5)* |
| Comorbidity | Diabetes mellitus (type 2) | | | | | No | 83 (87.4)* | 97 (92.4)* | 0.364 | 180 (90.0)* | Yes | 12 (12.6)* | 8 (7.6)* | 20 (10.0)* | Hypertension | | | | | No | 61 (64.2)* | 81 (77.1)* | 0.044 | 142 (71.0)* | Yes | 34 (35.8)* | 24 (22.9)* | 58 (29.0)* |
| Internal medical therapies | Proton pump inhibitor (PPI) | | | | | Nonuser | 63 (66.3)* | 79 (75.2)* | 0.165 | 142 (71.0)* | User | 32 (33.7)* | 26 (24.8)* | 58 (29.0)* | Low dose aspirin (LDA) | | | | | Nonuser | 82 (86.3)* | 96 (91.4)* | 0.267 | 178 (89.0)* | User | 13 (13.7)* | 9 (8.6)* | 22 (11.0)* |
| Lumber DXA | Bone mineral density (BMD) ()
| 0.96 (±0.14)** | 0.81 (±0.16)** | <0.001 | 0.88 (±0.17)** | Young adult mean (YAM) (%) | 91.1 (±13.5)** | 79.3 (±15.6)** | <0.001 | 84.9 (±15.7)** |
| Bone turnover marker | Bone specific ALP (BAP) (U/L) | 21.4 (±6.0)** | 23.4 (±6.6)** | 0.025 | 22.5 (±6.5)** | Collagen type-I cross-linked N-telopeptide (NTX) (nmolBCE/L) | 13.6 (±4.8)** | 14.8 (±5.2)** | 0.112 | 14.2 (±5.0)** |
| Upper GI findings | Reflux esophagitis (RE) | | | | | No | 89 (93.7)* | 102 (97.1)* | 0.313 | 191 (95.5)* | Yes | 6 (6.3)* | 3 (2.9)* | 9 (4.5)* | LA-grade A | 4 | 3 | 7 | Grade B | 2 | 0 | 2 | Grade C | 0 | 0 | 0 | Grade D | 0 | 0 | 0 | Hiatal hernia | | | | | No | 47 (49.5)* | 62 (59.0)* | 0.175 | 109 (54.5)* | Yes | 48 (50.5)* | 43 (41.0)* | 91 (45.5)* | Peptic ulcer disease (PUD) | | | | | No | 83 (87.4)* | 91 (86.7)* | 0.883 | 174 (87.0)* | Yes | 12 (12.6)* | 14 (13.3)* | 26 (13.0)* | Gastric ulcer | 5 | 10 | 15 | Duodenal ulcer | 4 | 2 | 6 | Gastroduodenal ulcer | 3 | 2 | 5 | Endoscopic gastric mucosal atrophy (EGA) | 1.9 (±1.8)** | 1.8 (±2.0)** | 0.811 | 1.8 (±1.9)** | C-0 | 28 | 38 | 66 | C-1 | 26 | 25 | 51 | C-2 | 11 | 7 | 18 | C-3 | 3 | 9 | 12 | O-1 | 16 | 11 | 27 | O-2 | 9 | 10 | 19 | O-3 | 2 | 5 | 7 |
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(%), **median (±SD).
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