Gastroenterology Research and Practice / 2014 / Article / Tab 2 / Research Article
Aberrant Expression of MicroRNA-15a and MicroRNA-16 Synergistically Associates with Tumor Progression and Prognosis in Patients with Colorectal Cancer Table 2 Prognostic value of combined miR-15a and miR-16 expression for the disease-free survival and overall survival in univariate and multivariate analyses by Cox regression.
Disease-free survival Overall survival Hazard ratio (95% CI) Hazard ratio (95% CI) Univariate Gender 1.005 (0.101–2.208) NS 1.298 (0.122–2.891) NS Age 1.091 (0.198–2.623) NS 1.255 (0.226–2.879) NS Site of primary tumor 0.698 (0.119–5.516) NS 0.869 (0.126–1.881) NS Tumor size 0.379 (0.103–0.743) NS 0.799 (0.136–1.606) NS Depth of tumor invasion 0.462 (0.102–1.039) NS 0.729 (0.108–1.692) NS Lymph node metastasis 3.232 (1.566–6.676) 0.01 3.528 (1.616–7.869) 0.008 TNM stage 5.069 (1.981–12.620) <0.001 5.869 (1.996–12.788) <0.001 Histological grade 3.982 (1.119–8.116) 0.006 4.569 (1.126–10.281) 0.001 miR-15a 4.336 (1.201–9.682) 0.001 4.628 (1.128–10.161) 0.001 miR-16 4.283 (1.123–9.416) 0.001 4.562 (1.121–10.286) 0.001 miR-15a/miR-16 5.019 (1.972–12.069) <0.001 5.712 (1.982–12.689) <0.001 Multivariate Lymph node metastasis 2.058 (1.013–4.621) 0.02 2.655 (1.039–5.528) 0.01 Histological grade 2.698 (1.119–5.516) 0.01 2.869 (1.126–5.881) 0.01 miR-15a 2.782 (1.122–6.031) 0.01 3.016 (1.129–6.616) 0.01 miR-16 2.598 (1.013–6.006) 0.01 2.912 (1.110–6.011) 0.01 miR-15a/miR-16 4.818 (1.937–10.129) <0.001 4.983 (1.946–10.962) <0.001