Prognostic and Predictive Value of CpG Island Methylator Phenotype in Patients with Locally Advanced Nonmetastatic Sporadic Colorectal Cancer
Table 1
Clinicopathological characteristics associated with CIMP status.
CIMP−
CIMP+
value
No. (%)
No. (%)
Age (yr)
0.270
Mean ± SD
Sex
0.750
Male
17 (44.7)
6 (50.0)
Female
21 (55.3)
6 (50.0)
Sitea
0.046
Proximal
5 (13.2)
5 (41.7)
Distal
33 (86.8)
7 (58.3)
Stage
0.022
II
17 (44.7)
1 (8.3)
III
21 (55.3)
11 (91.7)
Histology
0.059
Adenocarcinoma
32 (84.2)
7 (58.3)
Mucinous adenocarcinoma
6 (15.8)
5 (41.7)
Grade
0.007
Well/moderate
31 (81.6)
5 (41.7)
Poor
7 (18.4)
7 (58.3)
Lymphovascular invasion
0.121
Present
3 (8.1)
3 (25.0)
Absent
34 (91.9)
9 (75.0)
Perineural invasion
0.961
Present
3 (7.9)
1 (8.3)
Absent
35 (92.1)
11 (91.7)
CEA level
0.802
Normal
28 (80.0)
10 (83.3)
Elevated
7 (20.0)
2 (16.7)
Adjuvant chemotherapy
0.637
Not received
10 (26.3)
4 (33.3)
Received
28 (73.7)
8 (66.7)
SD: standard deviation, CIMP: CpG island methylator phenotype, CEA: carcinoembryonic antigen.
aProximal location included the cecum, ascending colon, hepatic flexure of colon, and transverse colon while distal location included the splenic flexure of colon, descending colon, sigmoid colon, and rectum.
