Table 2: Univariate and multivariate analysis of the prognostic effect of CIMP status and clinicopathological features in stage cases for DFS.

 Univariate analysisMultivariate analysisb
 No.5 yr DFS valueHR95% CI value

Age (yr)0.182
 ≤553069.7%
 >552055.0%
Sex0.990
 Male2364.6%
 Female2763.0%
Stage0.049 0.242
 II1883.3%1reference
 III3252.9%3.075(0.468–20.205)
Sitea0.092
 Proximal1040.0%
 Distal4069.6%
Histology0.671
 Adenocarcinoma3966.7%
 Mucinous1153.0%
Grade0.681
 Well/moderate3666.7%
 Poor1456.3%
CEA level0.304
 Normal3856.3%
 Elevated944.4%
Adjuvant chemotherapy0.849
 Not received1471.4%
 Received3661.0%
CIMP epigenotype0.014 0.019
 Negative3873.7%1reference
 Positive1231.3% 2.935(1.193–7.220) 

5-yr DFS: five-year disease-free survival, CIMP: CpG island methylator phenotype, CEA: carcinoembryonic antigen, HR: hazard ratio.
aProximal location included the cecum, ascending colon, hepatic flexure of colon, and transverse colon while distal location included the splenic flexure of colon, descending colon, sigmoid colon, and rectum.
bOnly factors which showed significant impact on DFS in the univariate analysis were included in the Cox regression analysis.