Prognostic and Predictive Value of CpG Island Methylator Phenotype in Patients with Locally Advanced Nonmetastatic Sporadic Colorectal Cancer

Table 3

Univariate analysis of the prognostic effect of CIMP status and clinicopathological features in stage II/III cases for OS.

	Univariate analysis^b
	No.	5-yr OS	𝑃 value
Age (yr)			0.078
≤55	30	74.2%
>55	20	58.5%
Sex			0.459
Male	23	60.5%
Female	27	74.4%
Stage			0.222
II	18	78.2%
III	32	62.2%
Site^a			0.117
Proximal	10	50.0%
Distal	40	82.0%
Histology			0.559
Adenocarcinoma	39	64.3%
Mucinous	11	81.8%
Grade			0.820
Well/moderate	36	65.2%
Poor	14	56.3%
CEA level			0.255
Normal	38	71.4%
Elevated	9	50.0%
Adjuvant chemotherapy			0.083
Not received	14	35.7%
Received	36	78.0%
CIMP epigenotype			0.354
Negative	38	69.0%
Positive	12	65.6%

5-yr OS: five-year overall survival, CIMP: CpG island methylator phenotype, CEA: carcinoembryonic antigen, HR: hazard ratio.
^aProximal location included the cecum, ascending colon, hepatic flexure of colon, and transverse colon while distal location included the splenic flexure of colon, descending colon, sigmoid colon, and rectum.
^bOnly univariate analysis was performed since all factors considered were not significantly associated with OS.