Table 3: Univariate analysis of the prognostic effect of CIMP status and clinicopathological features in stage cases for OS.

Univariate analysisb
No.5-yr OS value

Age (yr)0.078
 ≤553074.2%
 >552058.5%
Sex0.459
 Male2360.5%
 Female2774.4%
Stage0.222
 II1878.2%
 III3262.2%
Sitea0.117
 Proximal1050.0%
 Distal4082.0%
Histology0.559
 Adenocarcinoma3964.3%
 Mucinous1181.8%
Grade0.820
 Well/moderate3665.2%
 Poor1456.3%
CEA level0.255
 Normal3871.4%
 Elevated950.0%
Adjuvant chemotherapy0.083
 Not received1435.7%
 Received3678.0%
CIMP epigenotype0.354
 Negative3869.0%
 Positive1265.6% 

5-yr OS: five-year overall survival, CIMP: CpG island methylator phenotype, CEA: carcinoembryonic antigen, HR: hazard ratio.
aProximal location included the cecum, ascending colon, hepatic flexure of colon, and transverse colon while distal location included the splenic flexure of colon, descending colon, sigmoid colon, and rectum.
bOnly univariate analysis was performed since all factors considered were not significantly associated with OS.