- About this Journal ·
- Abstracting and Indexing ·
- Advance Access ·
- Aims and Scope ·
- Annual Issues ·
- Article Processing Charges ·
- Articles in Press ·
- Author Guidelines ·
- Bibliographic Information ·
- Citations to this Journal ·
- Contact Information ·
- Editorial Board ·
- Editorial Workflow ·
- Free eTOC Alerts ·
- Publication Ethics ·
- Reviewers Acknowledgment ·
- Submit a Manuscript ·
- Subscription Information ·
- Table of Contents
Gastroenterology Research and Practice
Volume 2014 (2014), Article ID 462856, 8 pages
Duodenal Chromogranin A Cell Density as a Biomarker for the Diagnosis of Irritable Bowel Syndrome
1Section for Gastroenterology, Department of Medicine, Stord Hospital, P.O. Box 4000, 54 09 Stord, Norway
2Section for Gastroenterology, Department of Clinical Medicine, University of Bergen, 5021 Bergen, Norway
3National Centre for Ultrasound in Gastroenterology, Department of Medicine, Haukeland University Hospital, 5021 Bergen, Norway
4Department of Research, Helse-Fonna, 5528 Haugesund, Norway
Received 7 February 2014; Accepted 3 May 2014; Published 16 June 2014
Academic Editor: Andrew Thillainayagam
Copyright © 2014 Magdy El-Salhy et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
- M. El-Salhy, D. Gundersen, J. G. Hatlebakk, and T. Hausken, Irritable Bowel Syndrome: Diagnosis, Pathogenesis and Treatment Options, Nova Science Publishers, New York, NY, USA, 2012.
- R. Spiller, M. Camilleri, and G. F. Longstreth, “Do the symptom-based, Rome criteria of irritable bowel syndrome lead to better diagnosis and treatment outcomes?” Clinical Gastroenterology and Hepatology, vol. 8, no. 2, p. 125, 2010.
- E. M. Quigley, “The “con” case. The Rome process and functional gastrointestinal disorders: the barbarians are at the gate!,” Neurogastroenterology and Motility, vol. 19, no. 10, pp. 793–797, 2007.
- P. Jellema, D. A. W. M. van der Windt, F. G. Schellevis, and H. E. van der Horst, “Systematic review: accuracy of symptom-based criteria for diagnosis of irritable bowel syndrome in primary care,” Alimentary Pharmacology and Therapeutics, vol. 30, no. 7, pp. 695–706, 2009.
- M. El-Salhy, “Irritable bowel syndrome: diagnosis and pathogenesis,” World Journal of Gastroenterology, vol. 18, no. 37, pp. 5151–5163, 2012.
- A. P. Manning, W. G. Thompson, K. W. Heaton, and A. F. Morris, “Towards positive diagnosis of the irritable bowel,” British Medical Journal, vol. 2, no. 6138, pp. 653–654, 1978.
- D. A. Drossman, “Rome III: the new criteria,” Chinese Journal of Digestive Diseases, vol. 7, no. 4, pp. 181–185, 2006.
- D. A. Drossman, “The functional gastrointestinal disorders and the Rome II process,” Gut, vol. 45, supplement 2, pp. 1–5, 1999.
- O. S. Lin, “Colonoscopy in irritable bowel syndrome: whom are we reassuring?” Gastrointestinal Endoscopy, vol. 62, no. 6, pp. 900–902, 2005.
- W. Kruis, C. Thieme, M. Weinzierl, P. Schüssler, J. Holl, and W. Paulus, “A diagnostic score for the irritable bowel syndrome. Its value in the exclusion of organic disease,” Gastroenterology, vol. 87, no. 1, pp. 1–7, 1984.
- S. Bellentani, P. Baldoni, S. Petrella et al., “A simple score for the identification of patients at high risk of organic diseases of the colon in the family doctor consulting room,” Family Practice, vol. 7, no. 4, pp. 307–312, 1990.
- T. N. Mazumdar, K. V. Prasad, and P. V. Bhat, “Formulation of a scoring chart for irritable bowel syndrome (IBS): a prospective study,” Indian Journal of Gastroenterology, vol. 7, no. 2, pp. 101–102, 1988.
- G. F. Longstreth, W. G. Thompson, W. D. Chey, L. A. Houghton, F. Mearin, and R. C. Spiller, “Functional bowel disorders,” Gastroenterology, vol. 130, no. 5, pp. 1480–1491, 2006.
- L. M. Gladman and D. A. Gorard, “General practitioner and hospital specialist attitudes to functional gastrointestinal disorders,” Alimentary Pharmacology and Therapeutics, vol. 17, no. 5, pp. 651–654, 2003.
- G. Barbara and V. Stanghellini, “Biomarkers in IBS: when will they replace symptoms for diagnosis and management?” Gut, vol. 58, no. 12, pp. 1571–1575, 2009.
- G. Barbara, C. Cremon, R. De Giorgio et al., “Mechanisms underlying visceral hypersensitivity in irritable bowel syndrome,” Current Gastroenterology Reports, vol. 13, no. 4, pp. 308–315, 2011.
- A. C. Ford, N. J. Talley, P. S. Schoenfeld, E. M. M. Quigley, and P. Moayyedi, “Efficacy of antidepressants and psychological therapies in irritable bowel syndrome: systematic review and meta-analysis,” Gut, vol. 58, no. 3, pp. 367–378, 2009.
- R. C. Spiller, “Potential biomarkers,” Gastroenterology Clinics of North America, vol. 40, no. 1, pp. 121–139, 2011.
- O. Sandström and M. El-Salhy, “Ageing and endocrine cells of human duodenum,” Mechanisms of Ageing and Development, vol. 108, no. 1, pp. 39–48, 1999.
- M. El-Salhy, K. Vaali, V. Dizdar, and T. Hausken, “Abnormal small-intestinal endocrine cells in patients with irritable bowel syndrome,” Digestive Diseases and Sciences, vol. 55, no. 12, pp. 3508–3513, 2010.
- L. Taupenot, K. L. Harper, and D. T. O'Connor, “The chromogranin-secretogranin family,” New England Journal of Medicine, vol. 348, no. 12, pp. 1134–1149, 2003.
- B. Wiedenmann and W. B. Huttner, “Synaptophysin and chromogranins/secretogranins - widespread constituents of distinct types of neuroendocrine vesicles and new tools in tumor diagnosis,” Virchows Archiv B: Cell Pathology Including Molecular Pathology, vol. 58, no. 2, pp. 95–121, 1989.
- L. J. Deftos, “Chromogranin A: its role in endocrine function and as an endocrine and neuroendocrine tumor marker,” Endocrine Reviews, vol. 12, no. 2, pp. 181–187, 1991.
- M. El-Salhy, B. Lomholt-Beck, and T. Hausken, “Chromogranin a as a possible tool in the diagnosis of irritable bowel syndrome,” Scandinavian Journal of Gastroenterology, vol. 45, no. 12, pp. 1435–1439, 2010.
- K. Sjolund, G. Sanden, R. Hakanson, and F. Sundler, “Endocrine cells in human intestine: an immunocytochemical study,” Gastroenterology, vol. 85, no. 5, pp. 1120–1130, 1983.
- M. El-Salhy, D. Gundersen, O. H. Gilja, J. G. Hatlebakk, and T. Hausken, “Is irritable bowel syndrome an organic disorder?” World Journal of Gastroenterology, vol. 20, no. 2, pp. 384–400, 2014.
- W. Lo, K. Sano, B. Lebwohl, B. Diamond, and P. H. R. Green, “Changing presentation of adult celiac disease,” Digestive Diseases and Sciences, vol. 48, no. 2, pp. 395–398, 2003.
- M. El-Salhy, B. Lomholt-Beck, and D. Gundersen, “The prevalence of celiac disease in patients with irritable bowel syndrome,” Molecular Medicine Reports, vol. 4, no. 3, pp. 403–405, 2011.
- E.-J. van der Wouden, G. F. Nelis, and J. Vecht, “Screening for coeliac disease in patients fulfilling the Rome II criteria for irritable bowel syndrome in a secondary care hospital in the Netherlands: a prospective observational study,” Gut, vol. 56, no. 3, pp. 444–445, 2007.
- G. R. Locke III, J. A. Murray, A. R. Zinsmeister, L. J. Melton III, and N. J. Talley, “Celiac disease serology in irritable bowel syndrome and dyspepsia: a population-based case-control study,” Mayo Clinic Proceedings, vol. 79, no. 4, pp. 476–482, 2004.
- H. Hin, G. Bird, P. Fisher, N. Mahy, and D. Jewell, “Coeliac disease in primary care: case finding study,” British Medical Journal, vol. 318, no. 7177, pp. 164–167, 1999.
- B. Shahbazkhani, M. Forootan, S. Merat et al., “Coeliac disease presenting with symptoms of irritable bowel syndrome,” Alimentary Pharmacology and Therapeutics, vol. 18, no. 2, pp. 231–235, 2003.
- C. Catassi, D. Kryszak, O. Louis-Jacques et al., “Detection of celiac disease in primary care: a multicenter case-finding study in North America,” The American Journal of Gastroenterology, vol. 102, no. 7, pp. 1454–1460, 2007.
- E. Korkut, M. Bektas, E. Oztas, M. Kurt, H. Cetinkaya, and A. Ozden, “The prevalence of celiac disease in patients fulfilling Rome III criteria for irritable bowel syndrome,” European Journal of Internal Medicine, vol. 21, no. 5, pp. 389–392, 2010.
- D. S. Sanders, D. Patel, T. J. Stephenson et al., “A primary care cross-sectional study of undiagnosed adult coeliac disease,” European Journal of Gastroenterology and Hepatology, vol. 15, no. 4, pp. 407–413, 2003.
- E. F. Verdu, D. Armstrong, and J. A. Murray, “Between celiac disease and irritable bowel syndrome: the “no man's land” of gluten sensitivity,” The American Journal of Gastroenterology, vol. 104, no. 6, pp. 1587–1594, 2009.
- U. Wahnschaffe, J.-D. Schulzke, M. Zeitz, and R. Ullrich, “Predictors of clinical response to gluten-free diet in patients diagnosed with diarrhea-predominant irritable bowel syndrome,” Clinical Gastroenterology and Hepatology, vol. 5, no. 7, pp. 844–850, 2007.