Review Article

Diagnostic Performance of Des-γ-carboxy Prothrombin for Hepatocellular Carcinoma: A Meta-Analysis

Table 4

Results of the sensitivity analysis using 3 criteria.

Analytical perspectiveQuantitySEN  
(95% CI)
SPE  
(95% CI)
PLR  
(95% CI)
NLR  
(95% CI)
DOR  
(95% CI)
AUC

Included studies120.71  
(0.68, 0.73)
0.84  
(0.83, 0.86)
6.48  
(4.22, 9.93)
0.33  
(0.25, 0.43)
21.86  
(12.38, 38.60)
0.89300.8238
Studies scored A50.74  
(0.70, 0.78)
0.88  
(0.85, 0.91)
7.06  
(3.27, 15.21)
0.30  
(0.20, 0.47)
24.56  
(11.55, 52.23)
0.90080.8321
Used ELISA detection methods90.73  
(0.71, 0.76)
0.83  
(0.81, 0.85)
6.48  
(3.91, 10.73)
0.29  
(0.20, 0.41)
24.29  
(12.11, 48.70)
0.90010.8313
Ethnicity
 Asian80.66  
(0.63, 0.69)
0.89  
(0.86, 0.91)
6.16  
(3.83, 9.91)
0.39  
(0.29, 0.52)
17.39  
(10.61, 28.51)
0.87610.8066
 Caucasian40.77  
(0.74, 0.81)
0.80  
(0.77, 0.83)
7.06  
(2.54, 19.63)
0.22  
(0.12, 0.40)
34.44  
(7.02, 168.96)
0.92090.8544
Type
 Perspective20.58  
(0.49, 0.66)
0.92  
(0.87, 0.96)
8.78  
(2.30, 33.43)
0.41  
(0.24, 0.69)
22.77  
(10.72, 48.33)
0.50000.5000
 Retrospective100.72  
(0.69, 0.74)
0.84  
(0.81, 0.85)
6.17  
(3.90, 9.76)
0.31  
(0.23, 0.43)
21.62  
(11.41, 40.99)
0.88750.8181

SEN: sensitivity; SPE: specificity; PLR: positive likelihood ratio; NLR: negative likelihood ratio; DOR: diagnostic odds ratio; AUC: area under curve.