Fistuloclysis Improves Liver Function and Nutritional Status in Patients with High-Output Upper Enteric Fistula

Table 3

Laboratory and clinical variables before and after 28-day treatments in the two groups.

Variables	Groups	Baseline	Day 14	Day 28	Delta	𝑃^a Value
TB (𝜇mol/L)	Fistuloclysis	38.2±9.8	26.2±8.5	18.1±6.2	20.3±9.7	<𝟎.𝟎𝟎𝟏^∗
	Control	40.7±11.2	35.8±10.6	24.8±7.1	15.6±6.3	𝟎.𝟎𝟏𝟑^∗
	𝑃^b	0.243			𝟎.𝟎𝟒𝟎^∗
DB (𝜇mol/L)	Fistuloclysis	19.6±8.5	12.6±5.8	7.2±2.3	12.5±3.4	<𝟎.𝟎𝟎𝟏^∗
	Control	21.4±10.0	18.2±7.5	11.3±3.5	10.0±3.6	𝟎.𝟎𝟏𝟐^∗
	𝑃^b	0.139			𝟎.𝟎𝟏𝟏^∗
IB (𝜇mol/L)	Fistuloclysis	18.3±6.6	13.2±4.3	12.6±3.6	5.7±2.0	𝟎.𝟎𝟐𝟔^∗
	Control	19.1±7.1	17.7±5.6	13.2±4.4	5.9±1.5	𝟎.𝟎𝟒𝟑^∗
	𝑃^b	0.183			0.285
ALT (U/L)	Fistuloclysis	55.6±20.7	56.4±22.3	48.1±16.5	7.3±3.1	𝟎.𝟎𝟐𝟓^∗
	Control	50.5±17.6	62.5±25.1	53.6±15.7	3.2±1.2	0.181
	𝑃^b	0.058			𝟎.𝟎𝟑𝟑^∗
ALP (U/L)	Fistuloclysis	212.2±85.1	165.1±65.2	113.7±41.3	98.4±33.5	<𝟎.𝟎𝟎𝟏^∗
	Control	219.7±89.9	188.3±69.5	161.2±34.7	57.6±20.9	𝟎.𝟎𝟎𝟓^∗
	𝑃^b	0.182			<𝟎.𝟎𝟎𝟏^∗
GGT (U/L)	Fistuloclysis	210.9±90.1	106.2±44.7	53.4±23.9	157.5±52.6	<𝟎.𝟎𝟎𝟏^∗
	Control	223.4±62.4	177.2±70.3	103.7±37.5	119.8±38.5	<𝟎.𝟎𝟎𝟏^∗
	𝑃^b	0.422			𝟎.𝟎𝟏𝟗^∗
TP (g/L)	Fistuloclysis	56.7±16.6	65.2±17.3	78.5±25.1	21.8±8.7	<𝟎.𝟎𝟎𝟏^∗
	Control	58.9±11.8	62.1±27.3	69.7±28.4	10.7±2.1	𝟎.𝟎𝟑𝟐^∗
	𝑃^b	0.763			<𝟎.𝟎𝟎𝟏^∗
Alb (g/L)	Fistuloclysis	31.2±3.4	37.1±9.5	42.5±12.7	11.3±2.5	<𝟎.𝟎𝟎𝟏^∗
	Control	32.5±12.8	33.4±10.5	36.8±7.6	4.2±1.3	0.078
	𝑃^b	0.472			<𝟎.𝟎𝟎𝟏^∗
WBC (10^9/L)	Fistuloclysis	11.1±4.0	10.3±3.7	8.4±2.2	2.6±0.9	0.418
	Control	10.9±3.9	10.1±3.2	9.3±2.4	1.8±0.4	0.068
	𝑃^b	0.304			0.061
CRP (mg/L)	Fistuloclysis	12.6±3.5	14.4±6.1	10.1±3.7	2.3±1.1	0.073
	Control	15.2±3.8	12.4±4.9	13.8±4.2	1.5±0.5	0.081
	𝑃^b	𝟎.𝟎𝟎𝟒^∗			𝟎.𝟎𝟑𝟐^∗
Fistula output (mL/day)	Fistuloclysis	1306.2±281.1	753.0±254.5	519.6±173.2	786.6±285.8	<𝟎.𝟎𝟎𝟏^∗
	Control	1455.2±203.6	1020.5±312.3	1063.7±423.4	391.5±125.3	0.052
	𝑃^b	0.152			<𝟎.𝟎𝟎𝟏^∗

TB: total bilirubin; DB: direct bilirubin; IB: indirect bilirubin; ALT: alanine aminotransferase; ALP: alkaline phosphatase; GGT: 𝛾-glutamyltransferase; TP: total protein; Alb: albumin; WBC: white blood cells; CRP: C-reactive protein. Delta value was defined as the changes from baseline to day 28 for each variable. 𝑃^a indicated the time-dependent changes of variables within groups. 𝑃^b indicated comparisons between the fistuloclysis group and the control group (for the baseline value and the delta values, resp.). Data were presented as mean ± SD. 𝑃 value < 0.05 was deemed significant.