Immunohistochemical Expression of Dual-Specificity Protein Phosphatase 4 in Patients with Colorectal Adenocarcinoma

Table 1

DUSP4 expression in NL, TA, CA, LNM, and DM ( = 621).

Tissue samples		DUSP4 expression
		Negative (%); ( = 400)	Positive (%); ( = 221)	value^†
NL	23	21 (91.3)	2 (8.7)	<0.001	0.218
TA	50	48 (96.0)	2 (4.0)
CA	439	273 (62.2)	166 (37.8)
LNM	56	37 (66.1)	19 (33.9)
DM	53	21 (39.6)	32 (60.4)

Chi-square test for linear trend.
DUSP4: dual specificity protein phosphatase 4; NL: normal colorectal tissue; TA: tubular adenoma; CA: adenocarcinoma; LNM: lymph node metastasis; DM: distant metastasis; : Spearman’s rank correlation coefficient.