Association between Helicobacter pylori Infection and Chronic Urticaria: A Meta-Analysis

Table 1

Characteristics of included studies.

First author	Year	Country	Region	Study design	HP detection method	(+) in the urticaria	(+) in the controls	Study quality
								Selection	Comparability	Exposure
Valsecchi [14]	1998	Italy	Europe	C-C	ELISA, UBT	78/125	20/46	***	—	**
Hizal [15]	2000	Turkey	Middle East	C-C	Serum anti-HP IgG	25/61	4/15	**	—	**
Daudén [16]	2000	Spain	Europe	C-C	UBT	17/25	21/25	****	*	**
Höök-Nikanne [17]	2000	Finland	Europe	C-C	Serology (ELISA)	57/231	178/504	***	—	**
Hidvégi [18]	2001	Hungary	Europe	C-C	Serology (ELISA)	13/24	9/18	****	—	**
Fukuda [19]	2004	Japan	East Asia	C-C	Serum anti-HP IgG	26/50	48/100	***	**	**
Liutu [22]	2004	Finland	Europe	C-C	Serum anti-HP IgG, histology	17/21	9/20	**	—	**
Moreira [20]	2004	Brazil	South America	C-C	Serology (ELISA)	19/31	45/136	**	—	***
Mete [21]	2004	Turkey	Middle East	C-C	Serology (ELISA)	25/33	14/27	***	**	**
Galadari [23]	2006	UAE	Middle East	C-C	Serology (ELISA)	15/20	4/20	**	*	**
Sianturi [24]	2007	Indonesia	Southeast Asia	C-C	UBT	2/16	0/16	**	**	**
Yadav [8]	2008	India	South Asia	C-C	Histology	48/68	46/68	**	**	**
Abdou [9]	2009	Egypt	Middle East	C-C	Histology	20/35	4/10	***	—	**
Sadighha [25]	2009	Iran	Middle East	C-C	Serology (ELISA)	56/75	42/75	**	**	**
Kołacińska-Flont [26]	2012	Poland	Europe	C-C	Serum anti-HP IgG	33/50	37/55	**	**	**
Sun [27]	2014	China	East Asia	C-C	Serum anti-HP IgG	29/100	23/100	***	**	**

C-C: case-control; : Helicobacter pylori; CU: chronic urticaria; ELISA: enzyme-linked immunosorbent assay; Ig: immunoglobulin; UBT: urea breath test.
^*One point in Newcastle-Ottawa scale (NOS) score for quality of included studies. ^**Two points in NOS score for quality of included studies. ^***Three points in NOS score for quality of included studies. ^****Four points in NOS score for quality of included studies. — stands for zero point in NOS score for quality of included studies.