Review Article
Assessing of Celiac Disease and Nonceliac Gluten Sensitivity
Table 1
Classification of CD subtypes.
| CD subtype | Symptoms | Serology+/HLA++ | Pathology classification | Marsh | Marsh-Oberhuber | Corazza |
| Classical | Gastrointestinal symptoms and signs (diarrhea, abdominal distension, constipation, and abdominal pain) | +/+ | Type 2/3* | Type 2/3a, b or c* | Grade A/B1 or B2* |
| Nonclassical | Extraintestinal symptoms and signs (anemia, neuropathy, osteoporosis, and short stature) | +/+ | Type 2/3 | Type 2/3a, b or c | Grade A/B1 or B2 |
| Subclinical | Asymptomatic | +/+ | Type 2/3 | Type 2/3a, b or c | Grade A/B1 or B2 |
| Potential | Presence or absence of symptoms | +/+ | Type 0/1** | Type 0/1** | Normal/Grade A** |
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+positive CD-specific serology (mainly IgA-EMA, IgA-tTG, and/or IgG-DGP). ++Presence of genes/haplotype associated with CD (see Table 2). *Intraepithelial lymphocytosis (ā„25/100 enterocytes) with crypt hyperplasia (Marsh-Oberhuber type 2) and partial/total villous atrophy. **Normal architecture/intraepithelial lymphocytosis. References [21ā27].
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