Prognostic Value of Metastatic No.8p LNs in Patients with Gastric Cancer

Table 5

Univariate and multivariate analysis of prognostic factors on overall survival in patients gastric cancer based on Cox proportional hazards model.

Variables	Univariate	value	Multivariate	value
	HR (95% CI)		HR (95% CI)
Age (years)
>60	1
≤60	0.742 (0.524, 1.050)	0.092
Gastrectomy
Subtotal gastrectomy	1		1
Total gastrectomy	1.778 (1.251, 2.252)	0.001	1.166 (0795, 1.710)	0.443
Tumor location
Upper	1
Middle	0.652 (0.384, 1.107)	0.113
Lower	0.536 (0.363, 0.790)	0.002
Total	2.154 (0.772, 6.010)	0.083
Pathological degree
Differentiated	1
Undifferentiated	0.949 (0.653, 1.378)	0.782
Curative degree
R0	1		1
R1/R2	3.926 (2.095, 7.356)	0.000	2.452 (1.267, 4.746)	0.008
Lymphadenectomy
D1+	1
D2+	1.215 (0.810, 1.823)	0.347
T stage
T1	1		1
T2	3.257 (1.147, 9.246)	0.027	2.514 (0.856, 7.387)	0.094
T3	3.697 (1.170, 11.687)	0.026	2.724 (0.833, 8.911)	0.097
T4	7.791 (3.173, 19.128)	0.000	4.556 (1.725, 12.035)	0.002
N stage
N0	1		1
N1	1.513 (0.798, 2.870)	0.205	1.024 (0.527, 1.990)	0.943
N2	1.935 (1.082, 3.461)	0.026	1.124 (0.605, 2.088)	0.711
N3a	3.429 (2.110, 7.103)	0.000	1.771 (0.986, 3.182)	0.056
N3b	7.245 (4.075, 12.880)	0.000	3.644 (1.952, 6.801)	0.000
M stage
M0	1		1
M1	3.223 (2.137, 4.861)	0.000	1.551 (0.877, 2.744)	0.132
No.8p LNs status
Negative	1		1
Positive	3.101 (1.873, 5.136)	0.000	0.892 (0.469, 1.696)	0.728

Backward variable selection with selection criteria of 0.2 was conducted with all clinicopathologic variables. pTNM stage is based on the Japanese classification of gastric carcinoma: 3rd English edition.