Research Article
Pentraxin 3 Is a Predictor for Fibrosis and Arterial Stiffness in Patients with Nonalcoholic Fatty Liver Disease
Table 1
Baseline characteristics of study population.
| | Variables | NAFLD
() | Control
() | |
| | Age (year) | 33.8 ± 5.9 | 30.8 ± 5.1 | 0.054 | | Smoking (%) | 37.7 | 22.2 | 0.265 | | BMI (kg/m2) | 29.4 ± 3.2 | 23.8 ± 2.7 | <0.001 | | WC (cm) | 101.1 ± 8.1 | 89 ± 10.1 | <0.001 | | HC (cm) | 106.3 ± 6.8 | 99.8 ± 5.4 | <0.001 | | SBP (mmHg) | 129.4 ± 9.6 | 117.3 ± 8.4 | 0.023 | | DBP (mmHg) | 80.3 ± 7.9 | 71.1 ± 5.8 | <0.001 | | AST (U/L) | 61.9 ± 48.2 | 22.1 ± 4.9 | <0.001 | | ALT (U/L) | 107.2 ± 55.5 | 22.7 ± 8.1 | <0.001 | | GGT (U/L) | 70.9 ± 42.8 | 20.7 ± 7.9 | <0.001 | | FPG (mg/dL) | 97.8 ± 10.3 | 88.2 ± 6.6 | 0.001 | | 2 h OGTT (mg/dL) | 106.3 ± 26.6 | 91.1 ± 13.6 | 0.034 | | Creatinine (mg/dL) | 1 ± 0.1 | 1 ± 0.1 | 0.332 | | Uric acid (md/dL) | 6.9 ± 1.2 | 5.4 ± 0.9 | <0.001 | | LDL-C (mg/dL) | 129.4 ± 30.6 | 106.8 ± 33.3 | 0.011 | | HDL-C (mg/dL) | 42.4 ± 7.8 | 43.6 ± 10.1 | 0.795 | | TG (mg/dL) | 183.4 ± 103.7 | 142.6 ± 103.3 | 0.156 | | Insulin (mU/mL) | 17.4 ± 10 | 10.7 ± 5.5 | 0.014 | | HOMA-IR | 4.3 ± 2.8 | 2.3 ± 1.1 | 0.007 | | Ferritin (ng/mL) | 166.1 ± 159.8 | 79.4 ± 57.3 | 0.003 | | hs-CRP (mg/dL) | 4.1 ± 3.7 | 1.7 ± 1.1 | 0.006 | | PTX3 (ng/mL) | 2.4 ± 1.9 | 1.7 ± 1.4 | 0.156 | | cf-PWV (m/s) | 8.3 ± 1.2 | 7.3 ± 1.2 | 0.006 | | CIMT (mm) | 0.451 ± 0.07 | 0.441 ± 0.07 | 0.653 | | FMD (%) | 11.2 ± 6.9 | 20.1 ± 11.9 | 0.014 |
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Mann-Whitney test was used for nonparametric tests.
NAFLD: nonalcoholic fatty liver disease, WC: waist circumference, HC: hip circumference, BMI: body mass index, SBP: systolic blood pressure, DBP: diastolic blood pressure, AST: aspartate aminotransferase, ALT: alanine aminotransferase, GGT: γ-glutamyltransferase, FPG: fasting plasma glucose, OGTT: oral glucose tolerance testing, LDL-C: low density lipoprotein cholesterol, HDL-C: high density lipoprotein cholesterol, TG: triglyceride, HOMA-IR: homeostasis model assessment of insulin resistance, hs-CRP: high sensitive c reactive protein, PTX3: pentraxin 3, cf-PWV: carotid femoral pulse wave velocity, CIMT: carotid intima media thickness, and FMD: flow mediated dilatation.
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