Serum Immunoglobulin A (IgA) Level Is a Potential Biomarker Indicating Cirrhosis during Chronic Hepatitis B Infection
Table 1
Demographic and clinical characteristics of the subjects.
Cirrhosis ()
Noncirrhosis ()
HCs ()
Gender (male/female)
83/21
52/18
38/17
0.313
Age (y)
54.0 ± 11.0
42.5 ± 12.5
44.8 ± 8.7
<0.001
Total protein (g/L)
61.1 ± 7.7
64.1 ± 6.7
70.5 ± 4.0
<0.001
Albumin (g/L)
29.8 ± 5.3
37.2 ± 6.2
45.6 ± 3.2
<0.001
ALT (U/L)
23.0 (14.0–38.8)
125.5 (40.3–301.0)
15.0 (11.0–21.0)
<0.001
AST (U/L)
36.0 (25.0–58.5)
81.5 (45.3–145.8)
19.0 (16.0–21.0)
<0.001
GGT (U/L)
40.5 (20.3–71.0)
65.0 (37.8–147.8)
18.5 (13.0–26.0)
<0.001
INR
1.40 ± 0.29
1.38 ± 0.44
0.93 ± 0.10
<0.001
Creatinine (mmol/L)
77.0 (66.0–94.0)
67.0 (58.5–81.5)
65.0 (55.0–79.0)
<0.001
Platelets (×109/L)
70.0 (43.0–122.0)
167.0 (103.3–202.5)
214.0 (180.3–244.0)
0.001
Hemoglobin (g/L)
101.0 (83.8–120.0)
138.0 (123.5–150.5)
137.5 (130.0–153.0)
<0.001
Blood urea nitrogen (mmol/L)
6.05 (4.50–8.15)
4.60 (3.90–5.40)
4.90 (4.22–5.60)
<0.001
HBsAg-positive ()
104
70
—
—
HBeAg-positive ()
60
70
—
—
HBV-DNA positive ()
104
70
—
—
Data are expressed as , mean ± SD, or median (interquartile range). ALT, alanine aminotransferase; AST, aspartate aminotransferase; GGT, gamma-glutamyl transferase; INR, international normalized ratio. , comparison among the three groups. , compared with noncirrhosis group. , compared with HCs group.
