Serum Immunoglobulin A (IgA) Level Is a Potential Biomarker Indicating Cirrhosis during Chronic Hepatitis B Infection
Table 2
Demographic and clinical characteristics of HBV-infected patients with compensated and decompensated cirrhosis at baseline.
Compensated ()
Decompensated ()
Gender (male/female)
57/15
27/5
0.745
Age (y)
52.3 ± 10.8
55.7 ± 11.7
0.303
Total protein (g/L)
62.2 ± 7.3
58.6 ± 8.1
0.027
Albumin (g/L)
32.0 ± 4.0
25.0 ± 4.8
<0.001
ALT (U/L)
21.0 (15.0–32.8)
33.5 (14.0–58.8)
0.145
AST (U/L)
31.0 (24.3–51.3)
46.5 (28.3–100.3)
0.001
Total bilirubin (μmol/L)
26.0 (16.0–43.0)
59.5 (25.0–179.0)
0.001
INR
1.34 ± 0.27
1.52 ± 0.31
0.005
Creatinine (mmol/L)
74.0 (63.0–86.0)
106.0 (70.3–124.0)
0.001
Platelets (×109/L)
62.0 (39.5–90.5)
72.0 (36.0–89.0)
0.001
Hemoglobin (g/L)
100.5 (81.0–124.0)
100.0 (88.5–116.0)
0.998
Encephalopathy ()
0
5
Hepatorenal syndrome ()
0
4
Ascites ()
10
32
Gastrointestinal bleeding ()
0
15
IgM (mg/dL)
151.0 (113.0–201.8)
159.5 (116.5–196.0)
0.833
IgA (mg/dL)
370.5 (244.3–506.5)
525.0 (378.3–673.5)
0.002
IgG (mg/dL)
1644.5 (1225.0–2124.8)
1969.0 (1302.5–2274.3)
0.204
Data are expressed as , mean ± SD, or median (interquartile range). ALT, alanine aminotransferase; AST, aspartate aminotransferase; INR, international normalized ratio; Ig, immunoglobulin.
