Review Article
Role of S100 Proteins in Colorectal Carcinogenesis
Table 1
Association of S100 proteins with different types of gastrointestinal cancer.
| Cancer site | Type of S100 protein | S100 regulated features | References |
| Colon | S100A8/A9, S100A4, S100A6, S100A11, S100B, S100P | ↑ | [25–28, 31–33, 41–47] |
| Oesophagus | S100A2 | ↓ in ESCC ↑ in adenocarcinoma | [48, 49] | S100A9 | ↑ in adenocarcinoma | [50] |
| Stomach | S100A2, S100A14 | ↓ | [51, 52] | S100A2, S100A3, S100A4, S100A6–S100A10 | ↑ |
[53–57] |
| Pancreas | S100A2 | Dysregulated | [58] | S100A4, S100P | ↑ | [59] | S100A11 | ↑ in early stage, ↓ in tumour progression | [60] |
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ESCC, oesophageal squamous cell carcinoma; ↑, upregulated; ↓, downregulated.
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