Prognostic Impact of mRNA Expression Levels of HER1–4 (ERBB1–4) in Patients with Locally Advanced Rectal Cancer

Table 3

Comparison of normalized gene expression values (40-ΔCq) in biopsies versus resected specimen in the adjuvant treatment group. Significant lower expression in resected specimen was observed for HER2–HER4 and MKI67 (n.s.: not significant).

Gene	Biopsy ()	Resected specimen ()	value
	Gene expression; median (range)	Gene expression; median (range)
EGFR (ERBB1, HER1)	34.8 (32.9–36.1)	34.6 (33.2–36.1)	n.s.
HER2 (ERBB2)	36.0 (34.6–37.2)	35.4 (34.3–36.5)	0.039
HER3 (ERBB3)	33.1 (31.9–34.5)	32.1 (30.6–33.4)	<0.001
HER4 (ERBB4)	32.9 (29.8–34.5)	31.8 (29.1–34.3)	<0.001
MKI67	35.4 (33.5–36.8)	35.1 (30.4–36.4)	0.02