Research Article
Molecular Analyses of Aspirated Cystic Fluid for the Differential Diagnosis of Cystic Lesions of the Pancreas: A Systematic Review and Meta-Analysis
Table 3
Accuracy measures of molecular diagnostic analyses for the differentiation of mucinous from nonmucinous pancreatic cysts.
| Test | Accuracy measure | Pooled summary measure# (95% CI) | value of heterogeneity test |
| KRAS mutation tests | Sensitivity | 0.47 (0.39–0.54) | 0.01‡ | Specificity | 0.98 (0.93–0.99) | 0.67 | Positive likelihood ratio | 10.03 (3.72–27.06) | 0.36 | Negative likelihood ratio | 0.56 (0.43–0.73) | 0.06 | Diagnostic odds ratio | 19.69 (5.91–65.58) | 0.27 |
| LOH tests | Sensitivity | 0.63 (0.54–0.71) | 0.17 | Specificity | 0.76 (0.63–0.87) | 0.18 | Positive likelihood ratio | 2.23 (1.35–3.66) | 0.67 | Negative likelihood ratio | 0.54 (0.42–0.70) | 0.61 | Diagnostic odds ratio | 4.65 (2.14–10.09) | 0.77 |
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#Random effects model. Chi-square or Fisher’s exact test for heterogeneity. ‡.
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