Molecular Analyses of Aspirated Cystic Fluid for the Differential Diagnosis of Cystic Lesions of the Pancreas: A Systematic Review and Meta-Analysis

Table 4

Accuracy measures of molecular diagnostic analyses for the differentiation of malignant from benign pancreatic cysts.

Test	Accuracy measure	Pooled summary measure^# (95% CI)	value of heterogeneity test
KRAS mutation tests	Sensitivity	0.59 (0.46–0.71)	0.02^‡
	Specificity	0.78 (0.71–0.85)	0.25
	Positive likelihood ratio	3.03 (1.79–5.11)	0.20
	Negative likelihood ratio	0.57 (0.32–0.99)	0.03^‡
	Diagnostic odds ratio	7.45 (2.15–25.81)	0.11
LOH tests	Sensitivity	0.89 (0.78–0.96)	0.57
	Specificity	0.69 (0.60–0.76)	0.15
	Positive likelihood ratio	2.57 (1.85–3.57)	0.28
	Negative likelihood ratio	0.19 (0.09–0.39)	0.81
	Diagnostic odds ratio	15.62 (6.28–38.87)	0.81

^#Random effects model. Chi-square or Fisher’s exact test for heterogeneity. ^‡.