Treatment with a Monoclonal Anti-IL-12p40 Antibody Induces Substantial Gut Microbiota Changes in an Experimental Colitis Model

Figure 3

Beta Diversity analysis separates nonactive disease [light-blue] (12p40-mAb [circles] and healthy [squares]) from active colitis mice [orange] (rat-IgG2a [circles] and NaCl [squares]). PCoA plot (unscaled) was determined through weighted UniFrac metrics (ANOSIM, , ) of the colonic microbiota from 32 mice. The ellipsoids highlight the degree of variation around each sample.