Treatment with a Monoclonal Anti-IL-12p40 Antibody Induces Substantial Gut Microbiota Changes in an Experimental Colitis Model

Figure 4

Pearson’s correlation of immunological and host parameters with changes in the relative distribution of microbiota members of the colonic content. On top of the heat map the immunological and host parameters are depicted. The lineages are marked on the right and are represented by five major taxonomic ranks. Symbols describing significant correlations were defined as follows: for value, + ≤ 0.05 and ≤ 0.01. For -value (False Discovery Rate correction), ≤ 0.05 and ≤ 0.01. A matrix containing the -values for every significant correlation is shown in Supplemental Table  4.