Treatment with a Monoclonal Anti-IL-12p40 Antibody Induces Substantial Gut Microbiota Changes in an Experimental Colitis Model

Figure 5

Bacterial prevalence in mice with high and low histopathology scores. Filled marks illustrate scores between 6 and 24, while empty marks illustrate those between 0 and 2. Samples in which RF32 (Alphaproteobacteria), Akkermansia (Illumina sequencing), and A. muciniphila (species-specific qPCR) were detected are represented by their relative distribution. Samples that were negative (no bacteria detected) are depicted at the no detection line. -values were determined with the False Discovery Rate correction method.