Treatment with a Monoclonal Anti-IL-12p40 Antibody Induces Substantial Gut Microbiota Changes in an Experimental Colitis Model

Table 2

Changes in taxa abundance between active colitis (rat-IgG2a and NaCl) and nonactive disease (12p40-mAb and healthy) determined by ANOVA.

Phylum	Class	Order	Family	Genus	Relative distribution		Significance
					Active colitis	Nonactive disease	value	-value
Bacteroidetes	Bacteroidia	Bacteroidales	Bacteroidaceae	Bacteroides	37.19%	11.32%	0.002	0.060
Bacteroidetes	Bacteroidia	Bacteroidales	[Paraprevotellaceae]	Unclassified	0.14%	0.05%	0.004	0.072
Firmicutes	Clostridia	Clostridiales	Ruminococcaceae	Ruminococcus	0.47%	3.89%	0.004	0.054
Firmicutes	Clostridia	Clostridiales	Unclassified	Unclassified	13.22%	26.45%	0.010	0.100
Firmicutes	Clostridia	Clostridiales	Ruminococcaceae	Oscillospira	2.20%	4.21%	0.029	0.225
Bacteroidetes	Bacteroidia	Bacteroidales	Porphyromonadaceae	Parabacteroides	0.68%	0.15%	0.044	0.288
TM7	TM7-3	CW040	F16	Unclassified	0.01%	0.02%	0.045	0.249

-values were determined with the False Discovery Rate correction method.