Cytoreductive Surgery plus Hyperthermic Intraperitoneal Chemotherapy for Management of Peritoneal Sarcomatosis: A Preliminary Single-Center Experience from Saudi Arabia

Table 3

Selected literature review on CRS + HIPEC for management of PS (till end of 2014).

Ref	Author	Year		HIPEC Chemo	CC-0/1	PCI	Median FU	Median DFS	Median OS	Median 5-year OS	Mortality	Morbidity	HS	Pathology
[6]	Rossi et al.	2004	60	Cis + dox	68	7.7	28	22	34	38	0	33	12	GIST = 14, RPS = 34, and LMS = 12
[21]	Lim et al.	2007	19	Cis	95	NR	NR	4.4	16.9	NR	0	16	15	GIST = 15, DSRCT = 3, and LS = 1
[21]	Lim et al.	2007	9	Cis + mitox	100	NR	NR	2.3	5.5	NR	11	44	16	GIST = 2, DSRCT = 2, LS = 1, sarcomatoid = 1, and unclassified = 3
[22]	Baratti et al.	2010	37	Cis + dox or MMC	84	14.7	104	12.1	26.2	24.3	2.7	21.6	NR	RPS = 13, uterine = 11, GIST = 8, DSRCT = 3, myxofibrosarcoma = 1, and LMS = 1
[8]	Salti et al.	2012	13	Cis + dox	70	12.1	12	11	12	NR	0	15.4	NR	LS = 8, pleomorphic sarcomas = 2, angiosarcoma = 1, and carcinosarcoma = 2
[23]	Baumgartner et al.	2013	17	Cis, dox or MMC	100	6	17.4	17.2	22.6	35	0	23.5	8	SCS = 4, LS = 5, LMS = 3, GIST = 2, and others = 3
[24]	Sommariva et al.	2013	15	Cis + dox or cis + MMC	100	5.5	28	15	27	29	0	46.6	NR	LS = 4, GIST = 2, LMS = 4, histiocytoma fibrous malignant = 1, DSRCT = 1, SCS = 1, schwannoma = 1, and stromal sarcoma = 1
[25]	Randle et al.	2013	10	Cis or mitox	60	NR	84.8	NR	21.6	50	0	NR	10	DSRCT = 1, fibrosarcoma = 1, LMS = 2, SS = 4, and hemangiopericytoma = 2
[26]	Bryan et al.	2014	18	MMC ± mitox	72.2	NR	NR	NR	40	56	5.6	33.3	8	GIST before era of TKI
	Current study	2015	11	Cis + dox or MMC or mel	100	14	12	18	28.3	NR	0	18.2	11	LS = 7, GIST = 2, uterine LMS = 2, and ES = 1

Ref: reference; HIPEC: hyperthermic intraperitoneal chemotherapy; Chemo: chemotherapy; CC: cytoreduction completeness; PCI: peritoneal cancer index; FU: follow-up; DFS: disease-free survival; OS: overall survival; HS: hospital stay; cis: cisplatin; dox: doxorubicin; mitox: mitoxantrone; MMC: mitomycin-c; Mel: melphalan; GIST: gastrointestinal stromal tumor; RPS: retroperitoneal sarcoma; LMS: leiomyosarcoma, LS: liposarcoma; DSRCT: desmoplastic small round cell tumor; SS: spindle-cell sarcoma; SCS: synovial cell sarcoma; TKI: tyrosine kinase inhibitor; NR: not reported.
3-year survival.
mean.
SPCI (simplified peritoneal cancer index).