Effect of Interval between Neoadjuvant Chemoradiotherapy and Surgery on Oncological Outcome for Rectal Cancer: A Systematic Review and Meta-Analysis

Table 2

The clinicopathologic data of the study populations.

Trial	Interval	Patient number	Mean age (years)	Gender		Interval range	Height from anal verge, cm	Preneoadjuvant therapy stage				pCR%	pCR ()	value
				Male	Female			I	II	III	IV
Moore et al. [6]	≤44 days	82	59	52	30	15∼206 days	6.1	3	28	51	0	12	10	0.19
	>44 days	73	62	46	27		6.4	3	21	49	0	19	14
Tran et al. [7]	≤8 weeks	16	62.3	10	6	8∼43 weeks	≤10 (NS)	0	8	8	0	6	1	0.19
	>8 weeks	32	58.1	18	14			1	18	11	1	9	3
Lim et al. [8]	2∼41 days	217	55.3	138	79	35.6 ± 3.3 days	4.8 ± 2.1		43 (I + II)	174	0	13.8	30	0.74
	42∼56 days	180	57.5	125	55	50.1 ± 4.4 days	4.8 ± 2.1		39 (I + II)	141	0	15	27
Tulchinsky et al. [9]	≤7 weeks	48	59	35	13	13∼173 days	5.6	0	39	6	0	16.7	8	0.03
	>7 weeks	84	64	54	30		6.2	0	63	17	0	34.5	29
Habr-Gama et al. [10]	≤12 weeks	121	56.9	65	56	9.8 ± 2.2 weeks	4.1 ± 1.7	10	50	23	0	13	11	0.2
	>12 weeks	129	60	83	46	25.8 ± 12.3 weeks	3.9 ± 1.8	7	57	25	0	8	6
de Campos-Lobato et al. [11]	<8 weeks	91	57	129	48	4∼14 weeks	5.5 (4–7)	0	53	28	0	16.2	13	0.027
	≥8 weeks	86					6 (3–7)	0	50	39	0	31.1	28
Evans et al. [12]	<6 weeks	18	66	60	35	3 days∼24 weeks	NS	NA	0	27	NA	5.6	1	NA
	6∼8 weeks	32						NA	6	23	NA	12.5	4
	>8 weeks	45						NA	10	34	NA	17.8	8
Wolthuis et al. [13]	≤7 weeks	201	64	124	77	28∼103 days	≤10	0	27	174	0	15.9	32	0.006
	>7 weeks	155	62	109	46	50∼103 days		0	14	141	0	28.4	43
Sloothaak et al. [14]	<8 weeks	312	63	200	112	1∼80 weeks	NS		74 (I + II)	198 (III + IV)		10.3	32	0.013
	8∼9 weeks	511	63	327	184				105 (I + II)	354 (III + IV)		13.1	67
	10∼11 weeks	406	64	244	162				68 (I + II)	306 (III + IV)		18	73
	≥12 weeks	364	64	229	135				68 (I + II)	255 (III + IV)		11.8	43
Jeong et al. [15]	<8 weeks	105	58.4	79	26	4∼14 weeks	4.8 ± 2.6	6	30	69	0	16.2	17	0.817
	≥8 weeks	48	56.4	38	10		4.7 ± 2.7	3	7	38	0	18	9
Fang et al. [16]	5∼6 weeks	32	NA	NA	NA	NA	mid and low rectal cancer	0	56	50	0	18.8	6	0.372
	≥6 weeks	74										12.2	9
Calvo et al. [17]	<6 weeks	136	65.5	91	45	4∼8 weeks	7.0		47	84		8.8	12	0.34
	≥6 weeks	199	66.0	109	90		7.0		45	147		12.1	24
Zeng et al. [18]	≤7 weeks	111	59	62	49	25–105 days	NS		32	79		15.3	17	0.029
	>7 weeks	122	59	68	54				28	94		27.1	33
You et al. [19]	≤7 weeks	139	55	96	43	4–14 weeks	NS		40	99		27.3	38	0.030
	>7 weeks	152	56	108	44				50	102		29.6	45
Sirohi et al. [20]	≤60 days	42	50	28	14	6–474 days	6		NA			14	6	0.24
	>60 days	68	48	50	18		4 ( = 0.045)					24	16

with data missing.
NA: data not available.