|
| Trial |
Interval | Sphincter-preserving procedure (%) | value | Median follow-up (months) | Local recurrence | Distant metastases | Overall survival |
|
| Moore et al. [6] | ≤44 days | 79.3 | 0.54 | | NA | | |
| >44 days | 83.6 | |
|
| Tran et al. [7] | ≤8 weeks | 75.0 | 1.0 | 27.7 | | 31% versus 34% (P = 0.53) | |
| >8 weeks | 75.0 | |
|
| Lim et al. [8] | 2∼41 days | 83.9 | 0.688 | 31 | Local recurrence-free survival (P = 0.1165) | | P = 0.8386 |
| 42∼56 days | 82.2 | |
|
| Tulchinsky et al. [9] | ≤7 weeks | 62.5 | 0.95 | 35 | 6% versus 4% (P = 0.67) | 19% versus 6% (P = 0.02) | |
| >7 weeks | 61.9 | 31 |
|
| Habr-Gama et al. [10] | ≤12 weeks | 52.9 | 0.003 | 46 | 34% versus 30% (P = 0.75) | 12% versus 12% (P = 0.999) | |
| >12 weeks | 34.1 | |
|
| de Campos-Lobato et al. [11] | <8 weeks | 72.3 | 0.86 | 59 | 10.5% versus 1.2% (P = 0.04) | 17.7% versus 14.1% (P = 0.85) | 85.5% versus 88.2% (P = 0.74) |
| ≥8 weeks | 72.3 | |
|
| Evans et al. [12] | <6 weeks | 83.3 | NA | | NA | | |
| 6∼8 weeks | 84.4 | |
| >8 weeks | 73.3 | |
|
| Wolthuis et al. [13] | ≤7 weeks | 86.1 | 0.18 | 4.99 years | 5 years free from recurrence: 73% versus 83% (P = 0.026) | 5-year cancer related survival: 83% versus 91% (P = 0.046) |
| >7 weeks | 78.7 | 4.73 years | |
|
| Sloothaak et al. [14] | | NA | NA | | NA | | |
|
| Jeong et al. [15] | <8 weeks | 82.4 | 0.341 | 38 | 3 years: 7.8% versus 12.7% (P = 0.279) | 3 years: 24% versus 18.9% (P = 0.427) | 3 years: 90.2% versus 87.2% (P = 0.825) |
| ≥8 weeks | 75 | |
|
| Fang et al. [16] | 5∼6 weeks | NA | NA | 32.2 | 3.1% versus 10.8% (P = 0.147) | 31.3% versus 14.9% (P = 0.052) | |
| ≥6 weeks | | |
|
| Calvo et al. [17] | <6 weeks
≥6 weeks | 64
68.3 | 0.4 | 71
| 5-year local control: 90.4% versus 94.5% (P = 0.123) | 5 years: 55.9 versus 70.4% (P = 0.014) |
| |
|
| Zeng et al. [18] | ≤7 weeks | 59.5 | 0.335 | 42 | 3 years: 12.9% versus 4.8% (P = 0.025) | 3 years: 14.4% versus 12.6% (P = 0.651) | 3 years: 89.0% versus 94.5% (P = 0.651) |
| >7 weeks | 65.6 | |
|
| You et al. [19] | ≤7 weeks
>7 weeks | 55.4
57.2 | 0.832 | 55
49 | 5-year DFS: 74.7% versus 66.8% (P = 0.248) | 5 years: 84.4% versus 75.3% (P = 0.679) |
| |
|
| Sirohi et al. [20] | ≤60 days | 62 | 0.357 | 13 | Overall recurrence: 14% versus 21% (P = 0.405) | |
| >60 days | 53 | | | |
|
