Review Article
From Pathogenesis, Clinical Manifestation, and Diagnosis to Treatment: An Overview on Autoimmune Pancreatitis
Table 1
Comparisons of the two types of AIP.
| Characteristics | Type 1 | Type 2 |
| Other nomenclatures [5] | LPSP | IDCP | AIP without GEL | AIP with GEL | IgG4 related | IgG4 unrelated |
| Ethnic [5] | Asia > United States, Europe | Europe > United States > Asian |
| Age [2, 5, 18] | 60 years or older | A decade younger |
| Sex [5] | Usually male | Equal |
| Symptom [5] | Obstructive jaundice often | Obstructive jaundice often | Abdominal pain rare | Abdominal pain common | Pancreas swelling common | Pancreas swelling common |
| Serology [2, 5] | High serum IgG4, auto-Ab+ | Normal serum IgG4, auto-Ab− |
| Histopathology [5] | Lymphocyte and plasmacyte infiltration and fibrosis | Granulocyte epithelial lesion often with destruction and obliteration of the pancreatic duct | Infiltration of IgG4 plasma cells |
| Extrapancreatic lesion [5, 15, 17] | Sclerosing cholangitis | Unrelated with OOI | Sclerosing sialadenitis | Retroperitoneal fibrosis, etc. |
| Ulcerative colitis [2, 5] | Rare | Often |
| Histology needed for diagnosis [5] | No | Yes |
| Respond to steroid [2, 5] | Responsive | Responsive |
| Relapse rate [5] | High | Low |
|
|