From Pathogenesis, Clinical Manifestation, and Diagnosis to Treatment: An Overview on Autoimmune Pancreatitis

Table 1

Comparisons of the two types of AIP.

Characteristics	Type 1	Type 2
Other nomenclatures [5]	LPSP	IDCP
	AIP without GEL	AIP with GEL
	IgG4 related	IgG4 unrelated
Ethnic [5]	Asia > United States, Europe	Europe > United States > Asian
Age [2, 5, 18]	60 years or older	A decade younger
Sex [5]	Usually male	Equal
Symptom [5]	Obstructive jaundice often	Obstructive jaundice often
	Abdominal pain rare	Abdominal pain common
	Pancreas swelling common	Pancreas swelling common
Serology [2, 5]	High serum IgG4, auto-Ab+	Normal serum IgG4, auto-Ab−
Histopathology [5]	Lymphocyte and plasmacyte infiltration and fibrosis	Granulocyte epithelial lesion often with destruction and obliteration of the pancreatic duct
	Infiltration of IgG4 plasma cells
Extrapancreatic lesion [5, 15, 17]	Sclerosing cholangitis	Unrelated with OOI
	Sclerosing sialadenitis
	Retroperitoneal fibrosis, etc.
Ulcerative colitis [2, 5]	Rare	Often
Histology needed for diagnosis [5]	No	Yes
Respond to steroid [2, 5]	Responsive	Responsive
Relapse rate [5]	High	Low