From Pathogenesis, Clinical Manifestation, and Diagnosis to Treatment: An Overview on Autoimmune Pancreatitis

Table 2

Genetic factors in the pathogenesis of AIP.

Gene related	Cells involved	Sites related	Possible function in AIP	Referencing
HLA-DRB10405-DQB10401	T cells	HLA-DRB10405-DQB10401 haplotype	Inducing an autoimmune response; genetic marker for non-HLA gene associated disease susceptibility	Kawa et al. [20]
FCRL3	B cells	FCRL3-110 alleles	Susceptibility with AIP	Umemura et al. [21]
CTLA4	T cells	+6230G/G; +49A/A	Being related with AIP resistance; marker of risk of relapse in AIP	Umemura et al. [22]
KCNA3	T cells	SNP (rs2840381, rs1058184, rs2640480, rs1319782)	T cell proliferation and activation	Ota et al. [23]
CFTR	—	Variants (1556V, 5T, S42F, etc.)	Predictors of a slow and reduced response to steroid treatment in AIP	Chang et al. [24]