Review Article
From Pathogenesis, Clinical Manifestation, and Diagnosis to Treatment: An Overview on Autoimmune Pancreatitis
Table 2
Genetic factors in the pathogenesis of AIP.
| Gene related | Cells involved | Sites related | Possible function in AIP | Referencing |
| HLA-DRB10405-DQB10401 | T cells | HLA-DRB10405-DQB10401 haplotype | Inducing an autoimmune response; genetic marker for non-HLA gene associated disease susceptibility | Kawa et al. [20] |
| FCRL3 | B cells | FCRL3-110 alleles | Susceptibility with AIP | Umemura et al. [21] |
| CTLA4 | T cells | +6230G/G +49A/A | Being related with AIP resistance; marker of risk of relapse in AIP | Umemura et al. [22] |
| KCNA3 | T cells | SNP (rs2840381, rs1058184, rs2640480, rs1319782) | T cell proliferation and activation | Ota et al. [23] |
| CFTR | ā | Variants (1556V, 5T, S42F, etc.) | Predictors of a slow and reduced response to steroid treatment in AIP | Chang et al. [24] |
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