Multimodality Treatment Including Triplet Regimen as First-Line Chemotherapy May Improve Prognosis of Serum AFP-Elevated Gastric Cancer with Liver Metastasis
Table 1
Comparison of characteristics of GCLM between the AFP ≥ 20 ng/ml group and AFP < 20 ng/ml group.
Variable
AFP ≥ 20 ng/ml ()
AFP < 20 ng/ml ()
Gender
Male
57 (77.0%)
198 (80.8%)
0.288
Female
17 (23.0%)
47 (19.2%)
Age (years)
≥65
56 (75.7%)
165 (67.3%)
0.111
<65
18 (24.3%)
80 (32.7%)
ECOG
0-1
66 (89.2%)
220 (89.8%)
0.514
2-3
8 (10.8%)
25 (10.2%)
Disease status
LM after radical resection
10 (13.5%)
45 (18.4%)
0.216
LM at first diagnosis
64 (86.5%)
200 (81.6%)
Primary lesion site
GEJ
24 (33.3%)
101 (42.4%)
0.385
Non-GEJ
48 (66.7%)
137 (57.6%)
Unknown
2
7
Histological type
Well differentiateda
23 (31.5%)
94 (39.3%)
<0.001
Poorly differentiatedb
40 (54.8%)
145 (60.7%)
GHA
10 (13.7%)
0 (0%)
Unknown
1
6
Lauren classification
Intestinal type
34 (70.8%)
103 (65.6%)
0.633
Diffused type
5 (10.4%)
25 (15.9%)
Mixed type
9 (18.8%)
29 (18.5%)
Unknown
26
88
HER2 status
Positive
13 (24.5%)
54 (30.9%)
0.240
Negative
40 (75.5%)
121 (69.1%)
Unknown
21
70
Peritoneal metastasis
Yes
9 (12.2%)
38 (15.5%)
0.321
No
65 (87.8%)
207 (84.5%)
Number of LM
1–3
12 (16.2%)
48 (20.3%)
0.367
>3
62 (83.8%)
188 (80.7%)
PVTT
Yes
11 (14.9%)
5 (2.0%)
<0.001
No
63 (85.1%)
240 (98.0%)
aIncluding well-differentiated and moderately differentiated adenocarcinoma. bIncluding poorly differentiated and signet ring cell adenocarcinoma. GHA = gastric hepatoid adenocarcinoma; ECOG = Eastern Cooperative Oncology Group; GEJ = gastroesophageal junction; HER2 = human epidermal growth factor receptor-2; AFP = α-fetoprotein; LM = liver metastasis; PVTT = portal vein tumor thrombus.
