TFCP2 Genetic Polymorphism Is Associated with Predisposition to and Transplant Prognosis of Hepatocellular Carcinoma

Table 2

Genotype distributions of the 7 SNPs in non-HCC and HCC groups.

	Genotype	Non-HCC	HCC	OR		OR
rs7959378	AA	60 (30)	54 (45)	1 (ref)		1 (ref)
	AC	94 (47)	49 (41)	0.58 (0.35–0.96)	0.034	0.64 (0.36–1.16)	0.141
	CC	46 (23)	16 (14)	0.39 (0.20–0.76)	0.006	0.43 (0.20–0.92)	0.030
	AC + CC	140 (70)	65 (55)	0.52 (0.32–0.83)	0.006	0.57 (0.33–0.98)	0.044
	A allele	214 (53)	157 (66)	1 (ref)		1 (ref)
	C allele	186 (47)	81 (34)	0.59 (0.43–0.83)	0.002	0.63 (0.43–0.93)	0.018
rs11169736	GG	127 (63)	76 (64)	1 (ref)		1 (ref)
	GT	66 (33)	41 (34)	1.04 (0.64–1.68)	0.879	0.98 (0.56–1.72)	0.954
	TT	7 (4)	2 (2)	0.48 (0.10–2.36)	0.364	0.25 (0.05–1.35)	0.108
	GT + TT	73 (37)	43 (36)	0.98 (0.61–1.58)	0.948	0.88 (0.51–1.51)	0.643
	G allele	320 (80)	193 (81)	1 (ref)		1 (ref)
	T allele	80 (20)	45 (19)	0.93 (0.62–1.40)	0.737	0.80 (0.51–1.27)	0.351
rs1056897	AA	8 (4)	2 (2)	1 (ref)		1 (ref)
	AG	69 (35)	39 (33)	2.26 (0.46–11.2)	0.317	3.79 (0.71–20.3)	0.121
	GG	123 (61)	78 (65)	2.54 (0.53–12.3)	0.247	4.49 (0.85–23.6)	0.076
	AA + AG	192 (96)	117 (98)	2.44 (0.51–11.7)	0.265	4.20 (0.81–21.8)	0.087
	A allele	85 (21)	43 (18)	1 (ref)		1 (ref)
	G allele	315 (79)	195 (82)	1.22 (0.81–1.84)	0.332	1.40 (0.89–2.23)	0.147
rs11169735	CC	115 (58)	78 (65)	1 (ref)		1 (ref)
	CT	70 (35)	38 (32)	0.80 (0.49–1.30)	0.372	0.94 (0.54–1.64)	0.822
	TT	15 (7)	3 (3)	0.30 (0.08–1.05)	0.060	0.63 (0.16–2.51)	0.514
	CT + TT	85 (42)	41 (35)	0.71 (0.44–1.14)	0.156	0.90 (0.52–1.54)	0.698
	C allele	300 (75)	194 (81)	1 (ref)		1 (ref)
	T allele	100 (25)	44 (19)	0.68 (0.46–1.01)	0.058	0.88 (0.56–1.39)	0.584
rs12820966	AA	130 (65)	79 (66)	1 (ref)		1 (ref)
	AC	62 (31)	38 (32)	1.01 (0.62–1.65)	0.973	0.95 (0.54–1.68)	0.864
	CC	8 (4)	2 (2)	0.41 (0.09–1.99)	0.269	0.25 (0.05–1.31)	0.101
	AC + CC	70 (35)	40 (34)	0.94 (0.58–1.52)	0.801	0.84 (0.49–1.46)	0.542
	A allele	322 (80)	196 (82)	1 (ref)		1 (ref)
	C allele	78 (20)	42 (18)	0.89 (0.58–1.34)	0.563	0.77 (0.48–1.23)	0.273
rs10876135	GG	129 (64)	91 (76)	1 (ref)		1 (ref)
	GA	66 (33)	27 (23)	0.28 (0.03–2.47)	0.254	0.53 (0.05–5.42)	0.591
	AA	5 (3)	1 (1)	0.58 (0.34–0.97)	0.041	0.69 (0.39–1.25)	0.223
	GA + AA	71 (36)	28 (24)	0.56 (0.34–0.93)	0.026	0.69 (0.38–1.22)	0.199
	G allele	324 (81)	209 (88)	1 (ref)		1 (ref)
	A allele	76 (19)	29 (12)	0.59 (0.37–0.94)	0.026	0.72 (0.43–1.21)	0.214
rs10099	CC	78 (39)	56 (47)	1 (ref)		1 (ref)
	CT	87 (44)	51 (43)	0.82 (0.50–1.33)	0.415	1.0 (0.56–1.76)	0.986
	TT	35 (17)	12 (10)	0.48 (0.23–1.00)	0.050	0.49 (0.22–1.10)	0.083
	CT + TT	122 (61)	63 (53)	0.72 (0.46–1.14)	0.159	0.83 (0.49–1.40)	0.479
	C allele	243 (61)	163 (68)	1 (ref)		1 (ref)
	T allele	157 (39)	75 (32)	0.71 (0.51–1.0)	0.050	0.74 (0.51–1.10)	0.132

value or odds ratio after adjusting for gender, MELD score, and Child score. OR, odds ratio. Values in italics indicate significance.