TFCP2 Genetic Polymorphism Is Associated with Predisposition to and Transplant Prognosis of Hepatocellular Carcinoma

Table 3

Association between the TFCP2 rs7959378 genotype and survival in HCC patients after LT.

rs7959378	RFS				OS
	HR		HR		HR		HR
General		0.014		0.041		0.003		0.021
AA	1 (ref)		1 (ref)				1 (ref)
AC	0.46 (0.24–0.91)	0.026	0.46 (0.23–0.94)	0.033	0.22 (0.08–0.59)	0.003	0.27 (0.10–0.75)	0.012
CC	0.19 (0.05–0.81)	0.025	0.25 (0.06–1.14)	0.073	0.13 (0.02–1.00)	0.050	0.16 (0.02–1.23)	0.123
Dominant
AA	1 (ref)		1 (ref)		1 (ref)		1 (ref)
AC + CC	0.39 (0.20–0.75)	0.005	0.42 (0.21–0.84)	0.014	0.20 (0.08–0.50)	0.001	0.25 (0.08–0.59)	0.006
Recessive
AA + AC	1 (ref)		1 (ref)		1 (ref)		1 (ref)
CC	0.27 (0.07–1.13)	0.073	0.39 (0.09–1.66)	0.201	0.23 (0.03–1.73)	0.155	0.34 (0.05–2.60)	0.299

Adjusted by AFP, tumor size and tumor number, and differentiation. RFS, relapse-free survival, OS, overall survival. HR, hazard ratio. Values in italics indicate significance.