Clinical Study

Risk Factors for Additional Surgery after Iatrogenic Perforations due to Endoscopic Submucosal Dissection

Table 3

A univariate analysis of variables associated with surgery caused by gastric perforation after endoscopic resection.

VariableNonsurgery group ()Surgery group () value

Age ≥ 70 (years)22 (36.7)2 (22.2)0.480
Male sex, n (%)38 (63.3)6 (66.7)1.000
Location (vertical), upper third, n (%)13 (21.7)3 (33.3)1.000
Location (circumferential), anterior, n (%)7 (11.7)7 (77.8)0.000
Resected size ≥ 3 (cm), n (%)49 (81.7)6 (66.7)0.373
Subepithelial lesion, n (%)6 (10.0)4 (44.4)0.021
ESD, n (%)51 (85.0)9 (100)0.594
En bloc resection, n (%)53 (88.3)9 (100)0.582
Macroperforation, n (%)37 (61.7)8 (88.9)0.147
Size of free air in the abdominal cavity ≥ 3 (cm), n (%)35 (58.3)3 (33.3)0.281
Abdominal pain score (NRS) ≥ 7, n (%)4 (6.7)2 (22.2)0.172
Postprocedure pain killer use ≥ 2, n (%)9 (15.0)7 (77.8)0.000
WBC count > 12,000/mm3, n (%)14 (23.3)3 (33.3)0.679
Body temperature (>37.0°C), n (%)9 (15.0)3 (33.3)0.183
Heart rate (≥100/min), n (%)3 (5.0)3 (33.3)0.026

ESD: endoscopic submucosal dissection.