Tumor Budding, uPA, and PAI-1 in Colorectal Cancer: Update of a Prospective Study

Table 3

Comparison of the results: test set versus validation set.

	uPA			PAI-1			Budding
	Test set mean values	Val. set mean values	Val.-set cut-off	Test set mean values	Val. set mean values	Val. set cut-off	Test set mean values	Val. set cut-off
Grading	Y	Y	Y		Y	Y	Y
T-stage		Y	T		Y	Y
N-stage					Y		Y	T
V-stage				Y	T			Y
M-stage		T	T		T	Y		Y

Y, statistically prognostic; N, not statistically prognostic; T, trend towards prognostic relevance; bold and italic fonts, concordance between test and validation set; bold italic font, discordance between test and validation set. according to cut-off stratification.